CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis

You-Chen Chao, Heng-Cheng Chu, Wei-Kuo Chang, Hsin-Hung Huang, Tsai-Yuan Hsieh

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

摘要

Aim: To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic pancreatitis and patients with alcoholic cirrhosis of liver are two different subpopulations. Methods: Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 (ALDH 2) in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver (n = 100), acute pancreatitis (n = 100), esophageal cancer (n = 82) and avascular necrosis of hip joint (AVN) (n = 53) and 194 non-alcoholic controls in a Chinese group. Results: The results showed that the carriage of T allele was not different among alcoholic patients with cirrhosis of liver, alcoholic patients with other complication and non-alcoholic controls. On the other hand, the carriage of the C allele was significantly more prevalent for alcoholic pancreatitis than for esophageal cancer (0.79 vs 0.60, P
原文英語
頁(從 - 到)6043-6048
頁數6
期刊World Journal of Gastroenterology
11
發行號38
出版狀態已發佈 - 2005
對外發佈Yes

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