Catalase-modulated heterogeneous fenton reaction for selective cancer cell eradication: SnFe2O4 nanocrystals as an effective reagent for treating lung cancer cells

Kuan Ting Lee, Yu Jen Lu, Fwu Long Mi, Thierry Burnouf, Yi Ting Wei, Shao Chieh Chiu, Er Yuan Chuang, Shih Yuan Lu

研究成果: 雜誌貢獻文章

27 引文 (Scopus)

摘要

Heterogeneous Fenton reactions have been proven to be an effective and promising selective cancer cell treatment method. The key working mechanism for this method to achieve the critical therapeutic selectivity however remains unclear. In this study, we proposed and demonstrated for the first time the critical role played by catalase in realizing the therapeutic selectivity for the heterogeneous Fenton reaction-driven cancer cell treatment. The heterogeneous Fenton reaction, with the lattice ferric ions of the solid catalyst capable of converting H2O2 to highly reactive hydroxyl radicals, can effectively eradicate cancer cells. In this study, SnFe2O4 nanocrystals, a recently discovered outstanding heterogeneous Fenton catalyst, were applied for selective killing of lung cancer cells. The SnFe2O4 nanocrystals, internalized into the cancer cells, can effectively convert endogenous H2O2 into highly reactive hydroxyl radicals to invoke an intensive cytotoxic effect on the cancer cells. On the other hand, catalase, present at a significantly higher concentration in normal cells than in cancer cells, remarkably can impede the apoptotic cell death induced by the internalized SnFe2O4 nanocrystals. According to the results obtained from the in vitro cytotoxicity study, the relevant oxidative attacks were effectively suppressed by the presence of normal physiological levels of catalase. The SnFe2O4 nanocrystals were thus proved to effect apoptotic cancer cell death through the heterogeneous Fenton reaction and were benign to cells possessing normal physiological levels of catalase. The catalase modulation of the involved heterogeneous Fenton reaction plays the key role in achieving selective cancer cell eradication for the hetero eneous Fenton reaction-driven cancer cell treatment.
原文英語
頁(從 - 到)1273-1279
頁數7
期刊ACS Applied Materials and Interfaces
9
發行號2
DOIs
出版狀態已發佈 - 一月 1 2017

指紋

Catalase
Nanocrystals
Cells
Cell death
Hydroxyl Radical
Catalysts
Cytotoxicity
Modulation
Ions

ASJC Scopus subject areas

  • Materials Science(all)

引用此文

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title = "Catalase-modulated heterogeneous fenton reaction for selective cancer cell eradication: SnFe2O4 nanocrystals as an effective reagent for treating lung cancer cells",
abstract = "Heterogeneous Fenton reactions have been proven to be an effective and promising selective cancer cell treatment method. The key working mechanism for this method to achieve the critical therapeutic selectivity however remains unclear. In this study, we proposed and demonstrated for the first time the critical role played by catalase in realizing the therapeutic selectivity for the heterogeneous Fenton reaction-driven cancer cell treatment. The heterogeneous Fenton reaction, with the lattice ferric ions of the solid catalyst capable of converting H2O2 to highly reactive hydroxyl radicals, can effectively eradicate cancer cells. In this study, SnFe2O4 nanocrystals, a recently discovered outstanding heterogeneous Fenton catalyst, were applied for selective killing of lung cancer cells. The SnFe2O4 nanocrystals, internalized into the cancer cells, can effectively convert endogenous H2O2 into highly reactive hydroxyl radicals to invoke an intensive cytotoxic effect on the cancer cells. On the other hand, catalase, present at a significantly higher concentration in normal cells than in cancer cells, remarkably can impede the apoptotic cell death induced by the internalized SnFe2O4 nanocrystals. According to the results obtained from the in vitro cytotoxicity study, the relevant oxidative attacks were effectively suppressed by the presence of normal physiological levels of catalase. The SnFe2O4 nanocrystals were thus proved to effect apoptotic cancer cell death through the heterogeneous Fenton reaction and were benign to cells possessing normal physiological levels of catalase. The catalase modulation of the involved heterogeneous Fenton reaction plays the key role in achieving selective cancer cell eradication for the hetero eneous Fenton reaction-driven cancer cell treatment.",
keywords = "Catalase modulation, Heterogeneous Fenton reaction, Hydrogen peroxide, Hydroxyl radicals, Lung cancer cell, Selective cancer therapy, SnFe2O4",
author = "Lee, {Kuan Ting} and Lu, {Yu Jen} and Mi, {Fwu Long} and Thierry Burnouf and Wei, {Yi Ting} and Chiu, {Shao Chieh} and Chuang, {Er Yuan} and Lu, {Shih Yuan}",
year = "2017",
month = "1",
day = "1",
doi = "10.1021/acsami.6b13529",
language = "English",
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journal = "ACS applied materials & interfaces",
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TY - JOUR

T1 - Catalase-modulated heterogeneous fenton reaction for selective cancer cell eradication

T2 - SnFe2O4 nanocrystals as an effective reagent for treating lung cancer cells

AU - Lee, Kuan Ting

AU - Lu, Yu Jen

AU - Mi, Fwu Long

AU - Burnouf, Thierry

AU - Wei, Yi Ting

AU - Chiu, Shao Chieh

AU - Chuang, Er Yuan

AU - Lu, Shih Yuan

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Heterogeneous Fenton reactions have been proven to be an effective and promising selective cancer cell treatment method. The key working mechanism for this method to achieve the critical therapeutic selectivity however remains unclear. In this study, we proposed and demonstrated for the first time the critical role played by catalase in realizing the therapeutic selectivity for the heterogeneous Fenton reaction-driven cancer cell treatment. The heterogeneous Fenton reaction, with the lattice ferric ions of the solid catalyst capable of converting H2O2 to highly reactive hydroxyl radicals, can effectively eradicate cancer cells. In this study, SnFe2O4 nanocrystals, a recently discovered outstanding heterogeneous Fenton catalyst, were applied for selective killing of lung cancer cells. The SnFe2O4 nanocrystals, internalized into the cancer cells, can effectively convert endogenous H2O2 into highly reactive hydroxyl radicals to invoke an intensive cytotoxic effect on the cancer cells. On the other hand, catalase, present at a significantly higher concentration in normal cells than in cancer cells, remarkably can impede the apoptotic cell death induced by the internalized SnFe2O4 nanocrystals. According to the results obtained from the in vitro cytotoxicity study, the relevant oxidative attacks were effectively suppressed by the presence of normal physiological levels of catalase. The SnFe2O4 nanocrystals were thus proved to effect apoptotic cancer cell death through the heterogeneous Fenton reaction and were benign to cells possessing normal physiological levels of catalase. The catalase modulation of the involved heterogeneous Fenton reaction plays the key role in achieving selective cancer cell eradication for the hetero eneous Fenton reaction-driven cancer cell treatment.

AB - Heterogeneous Fenton reactions have been proven to be an effective and promising selective cancer cell treatment method. The key working mechanism for this method to achieve the critical therapeutic selectivity however remains unclear. In this study, we proposed and demonstrated for the first time the critical role played by catalase in realizing the therapeutic selectivity for the heterogeneous Fenton reaction-driven cancer cell treatment. The heterogeneous Fenton reaction, with the lattice ferric ions of the solid catalyst capable of converting H2O2 to highly reactive hydroxyl radicals, can effectively eradicate cancer cells. In this study, SnFe2O4 nanocrystals, a recently discovered outstanding heterogeneous Fenton catalyst, were applied for selective killing of lung cancer cells. The SnFe2O4 nanocrystals, internalized into the cancer cells, can effectively convert endogenous H2O2 into highly reactive hydroxyl radicals to invoke an intensive cytotoxic effect on the cancer cells. On the other hand, catalase, present at a significantly higher concentration in normal cells than in cancer cells, remarkably can impede the apoptotic cell death induced by the internalized SnFe2O4 nanocrystals. According to the results obtained from the in vitro cytotoxicity study, the relevant oxidative attacks were effectively suppressed by the presence of normal physiological levels of catalase. The SnFe2O4 nanocrystals were thus proved to effect apoptotic cancer cell death through the heterogeneous Fenton reaction and were benign to cells possessing normal physiological levels of catalase. The catalase modulation of the involved heterogeneous Fenton reaction plays the key role in achieving selective cancer cell eradication for the hetero eneous Fenton reaction-driven cancer cell treatment.

KW - Catalase modulation

KW - Heterogeneous Fenton reaction

KW - Hydrogen peroxide

KW - Hydroxyl radicals

KW - Lung cancer cell

KW - Selective cancer therapy

KW - SnFe2O4

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DO - 10.1021/acsami.6b13529

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JO - ACS applied materials & interfaces

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