Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells

Jaw Wen Chen, Feng Yen Lin, Yung Hsiang Chen, Tao Cheng Wu, Yuh Lien Chen, Shing Jong Lin

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40 引文 斯高帕斯(Scopus)

摘要

Objective - We tested the hypothesis that carvedilol, a β-adrenoceptor and α-adrenoceptor antagonist with potent antioxidant property, could inhibit tumor necrosis factor-α (TNF-α)-induced endothelial adhesiveness to human mononuclear cells (MNCs), an early sign of atherogenesis. Methods and Results -Circulating MNCs were isolated from the peripheral blood of healthy subjects. Compared with control condition, pretreatment of carvedilol (10 μmol/L for 18 hours) or probucol (5 μmol/L for 18 hours), but not propanolol, prazosin, or both propanolol and prazosin significantly decreased TNF-α-stimulated adhesiveness of cultured human aortic endothelial cells (HAECs) to MNCs. Carvedilol inhibited TNF-α-stimulated endothelial vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (66.0±2.0% and 55.60±1.0% of control, P

原文英語
頁(從 - 到)2075-2081
頁數7
期刊Arteriosclerosis, Thrombosis, and Vascular Biology
24
發行號11
DOIs
出版狀態已發佈 - 十一月 2004
對外發佈

ASJC Scopus subject areas

  • 心臟病學與心血管醫學

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