Cardiovascular protection of magnolol: Cell-type specificity and dose-related effects

Jennifer Hui Chun Ho, Chuang Ye Hong

研究成果: 雜誌貢獻文章同行評審

26 引文 斯高帕斯(Scopus)

摘要

Magnolia officinalis has been widely used in traditional Chinese medicine. Magnolol, an active component isolated from Magnolia officinalis, is known to be a cardiovascular protector since 1994. The multiplex mechanisms of magnolol on cardiovascular protection depends on cell types and dosages, and will be reviewed and discussed in this article. Magnolol under low and moderate dosage possesses the ability to protect heart from ischemic/ reperfusion injury, reduces atherosclerotic change, protects endothelial cell against apoptosis and inhibits neutrophil-endothelial adhesion. The moderate to high concentration of magnolol mainly acts on smooth muscle cells and platelets. Magnolol induces apoptosis in vascular smooth muscle cells at moderate concentration and inhibits proliferation at moderate and high concentration. High concentration of magnolol also abrogates platelet activation, aggregation and thrombus formation. Magnolol also serves as an smooth muscle relaxant only upon the high concentration. Oral intake of magnolol to reach the therapeutic level for cardiovascular protection is applicable, thus makes magnolol an agent of great potential for preventing cardiovascular diseases in high-risk patients.

原文英語
文章編號70
期刊Journal of Biomedical Science
19
發行號1
DOIs
出版狀態已發佈 - 2012

ASJC Scopus subject areas

  • 臨床生物化學
  • 分子生物學
  • 細胞生物學
  • 生物化學(醫學)
  • 內分泌學、糖尿病和代謝
  • 藥學(醫學)

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