Cardiotrophin-1 is associated with increased risk of arterial stiffness

Hao Chang Hung, Feng Hwa Lu, Horng Yih Ou, Hung Tsung Wu, Jin Shang Wu, Yi Ching Yang, Chih Jen Chang

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.
原文英語
頁(從 - 到)123-130
頁數8
期刊Biomarkers in Medicine
9
發行號2
DOIs
出版狀態已發佈 - 二月 1 2015
對外發佈Yes

指紋

Pulse Wave Analysis
Vascular Stiffness
Ankle
Arm
Stiffness
Prehypertension
Cholesterol
Medical problems
cardiotrophin 1
Regression analysis
C-Reactive Protein
HDL Cholesterol
Insulin Resistance
Logistics
Creatinine
Triglycerides
Homeostasis
Obesity
Logistic Models
Smoking

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

引用此文

Hung, H. C., Lu, F. H., Ou, H. Y., Wu, H. T., Wu, J. S., Yang, Y. C., & Chang, C. J. (2015). Cardiotrophin-1 is associated with increased risk of arterial stiffness. Biomarkers in Medicine, 9(2), 123-130. https://doi.org/10.2217/BMM.14.87

Cardiotrophin-1 is associated with increased risk of arterial stiffness. / Hung, Hao Chang; Lu, Feng Hwa; Ou, Horng Yih; Wu, Hung Tsung; Wu, Jin Shang; Yang, Yi Ching; Chang, Chih Jen.

於: Biomarkers in Medicine, 卷 9, 編號 2, 01.02.2015, p. 123-130.

研究成果: 雜誌貢獻文章

Hung, HC, Lu, FH, Ou, HY, Wu, HT, Wu, JS, Yang, YC & Chang, CJ 2015, 'Cardiotrophin-1 is associated with increased risk of arterial stiffness', Biomarkers in Medicine, 卷 9, 編號 2, 頁 123-130. https://doi.org/10.2217/BMM.14.87
Hung, Hao Chang ; Lu, Feng Hwa ; Ou, Horng Yih ; Wu, Hung Tsung ; Wu, Jin Shang ; Yang, Yi Ching ; Chang, Chih Jen. / Cardiotrophin-1 is associated with increased risk of arterial stiffness. 於: Biomarkers in Medicine. 2015 ; 卷 9, 編號 2. 頁 123-130.
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