Cardiotoxin III inhibits proliferation and migration of oral cancer cells through MAPK and MMP signaling

Ching Yu Yen, Shih Shin Liang, Lo Yi Han, Han Lin Chou, Chon Kit Chou, Shinne Ren Lin, Chien Chih Chiu

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

Cardiotoxin III (CTXIII), isolated from the snake venom of Formosan cobra Naja naja atra, has previously been found to induce apoptosis in many types of cancer. Early metastasis is typical for the progression of oral cancer. To modulate the cell migration behavior of oral cancer is one of the oral cancer therapies. In this study, the possible modulating effect of CTXIII on oral cancer migration is addressed. In the example of oral squamous carcinoma Ca9-22 cells, the cell viability was decreased by CTXIII treatment in a dose-responsive manner. In wound-healing assay, the cell migration of Ca9-22 cells was attenuated by CTXIII in a dose- and time-responsive manner. After CTXIII treatment, the MMP-2 and MMP-9 protein expressions were downregulated, and the phosphorylation of JNK and p38-MAPK was increased independent of ERK phosphorylation. In conclusion, CTXIII has antiproliferative and -migrating effects on oral cancer cells involving the p38-MAPK and MMP-2/-9 pathways.
原文英語
文章編號650946
期刊Scientific World Journal
2013
DOIs
出版狀態已發佈 - 2013

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)
  • 環境科學 (全部)
  • 醫藥 (全部)

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