Carbon dots prepared from ginger exhibiting efficient inhibition of human hepatocellular carcinoma cells

Chi Lin Li, Chung Mao Ou, Chih Ching Huang, Wei Cheng Wu, Yi Ping Chen, Tzu En Lin, Lin Chen Ho, Chia Wei Wang, Chung Chien Shih, Hang Cheng Zhou, Ying Chu Lee, Woan Fang Tzeng, Tzeon Jye Chiou, Sin Tak Chu, Jinshun Cang, Huan Tsung Chang

研究成果: 雜誌貢獻文章同行評審

162 引文 斯高帕斯(Scopus)

摘要

Fluorescent carbon nanodots (C-dots; 4.3 ± 0.8 nm) from fresh tender ginger juice provide high suppression of the growth of human hepatocellular carcinoma cells (HepG2), with low toxicity to normal mammary epithelial cells (MCF-10A) and normal liver cells (FL83B). The inhibition is selective to HepG2 over other tested cancer cells, including human lung cancer cell line (A549), human breast cancer cell line (MDA-MB-231), and human cervical cancer cell line (HeLa). Western blot results reveal that the C-dots up-regulate the expression of p53 protein only in the HepG2 cell line. The 50% inhibiting concentration (IC50) value of the C-dots on HepG2 cells is 0.35 mg mL-1. Image cytometry results show significant uptake of C-dots by HepG2 cells that induce intracellular production of reactive oxygen species (ROS, 18.2-fold increased), while other cells remain almost the same in ROS levels after treatment with C-dots (1.11 mg mL-1). The C-dots trigger the pro-apoptotic factor to promote HepG2 cell apoptosis. The C-dots effectively inhibit the growth of tumors in nude mice (104 ± 14 vs. 3.7 ± 0.2 mg with and without treatment within 14 days). This journal is

原文英語
頁(從 - 到)4564-4571
頁數8
期刊Journal of Materials Chemistry B
2
發行號28
DOIs
出版狀態已發佈 - 七月 28 2014
對外發佈

ASJC Scopus subject areas

  • 化學 (全部)
  • 生物醫學工程
  • 醫藥 (全部)
  • 材料科學(全部)

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