Candidemia in cancer patients: Impact of early removal of non-tunneled central venous catheters on outcome

C. Y. Liu, L. J. Huang, W. S. Wang, T. L. Chen, C. C. Yen, M. H. Yang, L. T. Hsiao, C. Y. Liu, P. M. Chen, T. J. Chiou

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47 引文 斯高帕斯(Scopus)

摘要

Objective: To explore the impact of retention of non-tunneled central venous catheters (CVCs) on survival in candidemic cancer patients, where CVCs are commonly used and essential. A second object was to determine whether early CVC removal would benefit a subset of cancer patients. Methods: We retrospectively evaluated 92 cancer patients who had a single, non-tunneled CVC in place. Patients were grouped according to CVC retention or removal; the later group was subdivided into early (CVC removed ≤72 h after candidemia onset) and late removal. A Cox regression model was used for determining risk factors of adverse outcome and Kaplan-Meier analyses for comparing in-hospital 3-30 day survival among subgroups. Results: Baseline characteristics were comparable between CVC retention (n = 20) or removal (n = 72) groups. CVC retention was a significant risk factor of poor outcome, independent of other significant prognostic host factors (hazard ratio 7.15, 95% confidence interval 3.51-14.53, p < 0.001). Patients of early CVC removal (n = 40) had significant better survival than those of late removal (n = 32) (p < 0.001). Conclusion: The results suggest that retention of CVCs has a negative impact on survival in candidemic cancer patients, and that early CVC removal should be considered in a subset of cancer patients with candidemia.

原文英語
頁(從 - 到)154-160
頁數7
期刊Journal of Infection
58
發行號2
DOIs
出版狀態已發佈 - 2月 2009
對外發佈

ASJC Scopus subject areas

  • 微生物學(醫學)
  • 傳染性疾病

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