Cancer-Secreted miR-105 destroys vascular endothelial barriers to promote metastasis

Weiying Zhou, Miranda Y. Fong, Yongfen Min, George Somlo, Liang Liu, Melanie R. Palomares, Yang Yu, Amy Chow, Sean Timothy Francis O'Connor, Andrew R. Chin, Yun Yen, Yafan Wang, Eric G. Marcusson, Peiguo Chu, Jun Wu, Xiwei Wu, Arthur Xuejun Li, Zhuo Li, Hanlin Gao, Xiubao Ren & 3 others Mark P. Boldin, Pengnian Charles Lin, Shizhen Emily Wang

研究成果: 雜誌貢獻文章

471 引文 (Scopus)

摘要

Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, exosome-mediated transfer of cancer-secreted miR-105 efficiently destroys tight junctions and the integrity of these natural barriers against metastasis. Overexpression of miR-105 in nonmetastatic cancer cells induces metastasis and vascular permeability in distant organs, whereas inhibition of miR-105 in highly metastatic tumors alleviates these effects. miR-105 can be detected in the circulation at the premetastatic stage, and its levels in the blood and tumor are associated with ZO-1 expression and metastatic progression in early-stage breast cancer.

原文英語
頁(從 - 到)501-515
頁數15
期刊Cancer Cell
25
發行號4
DOIs
出版狀態已發佈 - 四月 14 2014
對外發佈Yes

指紋

Blood Vessels
Neoplasm Metastasis
Neoplasms
Zonula Occludens-1 Protein
Breast Neoplasms
Exosomes
Tight Junctions
Capillary Permeability
MicroRNAs

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

引用此文

Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., ... Wang, S. E. (2014). Cancer-Secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell, 25(4), 501-515. https://doi.org/10.1016/j.ccr.2014.03.007

Cancer-Secreted miR-105 destroys vascular endothelial barriers to promote metastasis. / Zhou, Weiying; Fong, Miranda Y.; Min, Yongfen; Somlo, George; Liu, Liang; Palomares, Melanie R.; Yu, Yang; Chow, Amy; O'Connor, Sean Timothy Francis; Chin, Andrew R.; Yen, Yun; Wang, Yafan; Marcusson, Eric G.; Chu, Peiguo; Wu, Jun; Wu, Xiwei; Li, Arthur Xuejun; Li, Zhuo; Gao, Hanlin; Ren, Xiubao; Boldin, Mark P.; Lin, Pengnian Charles; Wang, Shizhen Emily.

於: Cancer Cell, 卷 25, 編號 4, 14.04.2014, p. 501-515.

研究成果: 雜誌貢獻文章

Zhou, W, Fong, MY, Min, Y, Somlo, G, Liu, L, Palomares, MR, Yu, Y, Chow, A, O'Connor, STF, Chin, AR, Yen, Y, Wang, Y, Marcusson, EG, Chu, P, Wu, J, Wu, X, Li, AX, Li, Z, Gao, H, Ren, X, Boldin, MP, Lin, PC & Wang, SE 2014, 'Cancer-Secreted miR-105 destroys vascular endothelial barriers to promote metastasis', Cancer Cell, 卷 25, 編號 4, 頁 501-515. https://doi.org/10.1016/j.ccr.2014.03.007
Zhou, Weiying ; Fong, Miranda Y. ; Min, Yongfen ; Somlo, George ; Liu, Liang ; Palomares, Melanie R. ; Yu, Yang ; Chow, Amy ; O'Connor, Sean Timothy Francis ; Chin, Andrew R. ; Yen, Yun ; Wang, Yafan ; Marcusson, Eric G. ; Chu, Peiguo ; Wu, Jun ; Wu, Xiwei ; Li, Arthur Xuejun ; Li, Zhuo ; Gao, Hanlin ; Ren, Xiubao ; Boldin, Mark P. ; Lin, Pengnian Charles ; Wang, Shizhen Emily. / Cancer-Secreted miR-105 destroys vascular endothelial barriers to promote metastasis. 於: Cancer Cell. 2014 ; 卷 25, 編號 4. 頁 501-515.
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abstract = "Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, exosome-mediated transfer of cancer-secreted miR-105 efficiently destroys tight junctions and the integrity of these natural barriers against metastasis. Overexpression of miR-105 in nonmetastatic cancer cells induces metastasis and vascular permeability in distant organs, whereas inhibition of miR-105 in highly metastatic tumors alleviates these effects. miR-105 can be detected in the circulation at the premetastatic stage, and its levels in the blood and tumor are associated with ZO-1 expression and metastatic progression in early-stage breast cancer.",
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AU - Li, Zhuo

AU - Gao, Hanlin

AU - Ren, Xiubao

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AU - Wang, Shizhen Emily

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