Camellia oleifera seed extract attenuated abdominal and hepatic fat accumulation in rats fed a high-fat diet

Hsin Yi Yang, Wan Ju Yeh, Jung Ko, Jiun Rong Chen

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

摘要

The objective of this study was to evaluate the effects of the hot-water extract of defatted Camellia oleifera seeds (CSE) on body and liver fat accumulation in rats. Forty rats were divided into 5 groups and each group was fed either an isocaloric control diet or a high-fat liquid diet with 0% (H), 0.12% (H1), 0.24% (H2), or 0.48% CSE (H3) for 8 weeks. Ingestion of the high-fat liquid diet increased abdominal and liver fat accumulation, although no difference was found in body weights compared with rats fed the control diet. We found that rats fed the H2 and H3 diets had lower plasma alanine aminotransferase activities than the H group in the fourth and eighth weeks. At the end of the study, the H2 and H3 groups also had lower epididymal and retroperitoneal fat masses, and all CSE groups had lower circulatory leptin levels than the H group. CSE consumption decreased hepatic fat accumulation in terms of liver triglycerides and a histopathology analysis, and ameliorated high-fat diet-induced elevation of hepatic tumor necrosis factor-α levels. We also found that CSE groups had lower malondialdehyde and hy-droxyproline levels in the liver. Our results suggested that CSE may exert beneficial effects through decreasing body fat accumulation and hepatic steatosis and regulating adipokine levels in diet-induced nonalcoholic fatty liver disease.
原文英語
頁(從 - 到)320-325
頁數6
期刊Applied Physiology, Nutrition and Metabolism
44
發行號3
DOIs
出版狀態已發佈 - 三月 2019

ASJC Scopus subject areas

  • Physiology (medical)
  • Nutrition and Dietetics
  • Physiology
  • Endocrinology, Diabetes and Metabolism

指紋 深入研究「Camellia oleifera seed extract attenuated abdominal and hepatic fat accumulation in rats fed a high-fat diet」主題。共同形成了獨特的指紋。

  • 引用此