Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice

Jui Chi Tsai, Yi Wen Lin, Chun Yao Huang, Feng Yen Lin, Chien Sung Tsai

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Human platelets express Toll-like receptors (TLR) 4. However, the mechanism by which TLR4 directly affects platelet aggregation and blood coagulation remains to be explored. Therefore, in this study, we evaluated the platelet TLR4 expression in patients who underwent CABG surgery; we explored the correlation between platelet TLR4 expression and the early outcomes in hospital of patients. Additionally, C57BL/6 and C57BL/6-TlrLPS-/- mice were used to explore the roles of platelet TLR4 in coagulation by platelet aggregometry and rotation thromboelastometry. In conclusion, our results highlight the important roles of TLR4 in blood coagulation and platelet function. Of clinical relevance, we also explored novel roles for platelet TLR4 that are associated with early outcomes in cardiac surgery.

原文英語
文章編號484510
期刊Mediators of Inflammation
2014
DOIs
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Medicine(all)

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