Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity

C. B. Yeh, Shao-Ju Weng, Kang-Wei Chang, J. Y.H. Chan, S. M. Huang, T. H. Chu, N. K. Wei, H. S. Ma, J. T. Cheng, K. H. Ma, T. H. Chen, J. F. Shyu

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Summary: Calcitonin may relieve pain by modulating central serotonin activity. Calcitonin partly reversed the hypersensitivity to pain induced by ovariectomy. This suggests that the anti-nociceptive effects of calcitonin in the treatment of osteoporosis may be mediated by alterations in neural serotonin transporter (SERT) activity. Introduction: This study used a rat model of osteoporosis to evaluate the role of the cerebral serotonin system in the anti-nociceptive effect of calcitonin, a drug used to treat post-menopausal osteoporosis. Methods: Osteoporosis was induced in rats by ovariectomy (OVX). Rats were then randomized to the following four groups: sham operation, OVX, OVX plus calcitonin, or OVX plus alendronate. Results: OVX led to alterations in bone micro-architecture; alendronate strongly reversed this effect, and calcitonin moderately reversed this effect. OVX increased hyperalgesia (determined as the time for hind paw withdrawal from a heat source); calcitonin reduced this effect, but alendronate had no effect. OVX increased the expression of c-Fos (a neuronal marker of pain) in the thalamus; calcitonin strongly reversed this effect, and alendronate moderately reversed this effect. OVX also reduced SERT but increased 5-HT1A receptor expression and activity; calcitonin aggravated this effect, but alendronate had no effect on recovery of SERT/5-HT1A activity and expression. Conclusions: Our study of a rat model of osteoporosis suggests that OVX-induced enhancement of the serotonergic system may protect against hyperalgesia. However, the anti-nociceptive effects of calcitonin in osteoporosis may be mediated by decreased neural SERT activity and increased activation of 5-HT1 receptors in the thalamu
原文英語
頁(從 - 到)3355-3364
頁數10
期刊Osteoporosis International
27
發行號11
DOIs
出版狀態已發佈 - 十一月 1 2016
對外發佈Yes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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    Yeh, C. B., Weng, S-J., Chang, K-W., Chan, J. Y. H., Huang, S. M., Chu, T. H., Wei, N. K., Ma, H. S., Cheng, J. T., Ma, K. H., Chen, T. H., & Shyu, J. F. (2016). Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity. Osteoporosis International, 27(11), 3355-3364. https://doi.org/10.1007/s00198-016-3652-1