Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats

Feng L. Hsu, Yun Chueh Chen, Juei Tang Cheng

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143 引文 斯高帕斯(Scopus)

摘要

The antihyperglycemic effect of caffeic acid, one of the phenolic compounds contained in the fruit of Xanthium strumarium, was investigated. After an intravenous injection of caffeic acid into diabetic rats of both streptozotocin-induced and insulin-resistant models, a dose-dependent decrease of plasma glucose was observed. However, a similar effect was not produced in normal rats. An insulin-independent action of caffeic acid can thus be considered. Otherwise, this compound reduced the elevation of plasma glucose level in insulin-resistant rats receiving a glucose challenge test. Also, glucose uptake into the isolated adipocytes was raised by caffeic acid in a concentration-dependent manner. Increase of glucose utilization by caffeic acid seems to be responsible for the lowering of plasma glucose.
原文英語
頁(從 - 到)228-230
頁數3
期刊Planta Medica
66
發行號3
DOIs
出版狀態已發佈 - 2000

ASJC Scopus subject areas

  • Plant Science
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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