C-myc activation in an unusual retrovirus-induced avian T-lymphoma resembling Marek's disease: Proviral insertion 5' of exon one enhances the expression of an intron promoter

R. Isfort, R. L. Witter, H. J. Kung

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Characterization of nonacute retrovirus-induced neoplasms have greatly facilitated our understanding of the mechanisms by which host protooncogenes are activated. Here we report the molecular characterization of a newly identified chicken lymphoma, which does not involve the bursa of Fabricius. This lymphoma, specifically induced by reticuloendotheliosis virus (REV), is similar in tumor location and T-cell origin to Marek's disease, a herpesvirus-induced T-lymphoma. We show the c-myc is the specific target locus for REV insertion. Integrated proviruses are all located upstream of the c-myc coding exons, and 60% are 5' to the first noncoding exon. One-half of the proviruses are oriented in the opposite transcriptional direction as the c-myc gene. This insertion pattern is in contrast to the pattern in B-lymphomas induced by the same virus. While some of the proviruses in these T-lymphomas used the 3' LTR promoter to transcribe the downstream c-myc gene, others apparently activated a common, cryptic promoter located in the first intron. To our knowledge, this is the first molecular description of an avian T-lymphoma induced by a nonacute retrovirus.
原文英語
頁(從 - 到)81-94
頁數14
期刊Oncogene Research
2
發行號1
出版狀態已發佈 - 十二月 1 1987
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research

指紋 深入研究「C-myc activation in an unusual retrovirus-induced avian T-lymphoma resembling Marek's disease: Proviral insertion 5' of exon one enhances the expression of an intron promoter」主題。共同形成了獨特的指紋。

引用此