Tumor cells that retained their original histology were grown from a biopsy taken from a 7-year-ofd male with a Burkitt tumor. The cells grew in suspension, usually in clumps varying from a few to hundreds of cells in a free-floating mass. This cell line was designated SL1. A herpes-like virus, which caused some cell degeneration of the tumor cells in culture, was observed by electron microscopy. Supernatant fluids from the SL1 cultures failed to produce a cytopathogenic effect in inoculated cell lines. A specific chromosome alteration was observed in the cells from the original tumor and in the cultured tumor cells.
ASJC Scopus subject areas
- Cancer Research
Stewart, S. E., Lovelace, E., Whang, J. J., & Ngu, V. A. (1965). Burkitt tumor: Tissue culture, cytogenetic and virus studies. Journal of the National Cancer Institute, 34(2), 319-327. https://doi.org/10.1093/jnci/34.2.319