Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells

Szu Yuan Wu, Ming De Yan, Alexander T H Wu, Kevin Sheng Po Yuan, Shing Hwa Liu

研究成果: 雜誌貢獻 › 文章

8 引文 (Scopus)

摘要

In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and phosphatase and tensin homolog (PTEN), respectively. Moreover, fucoidan reduced the luciferase activity of 3'-untranslated region reporter; treatment of cells with the miR-29c mimic or miR-17-5p inhibitor also produced similar results. These effects of fucoidan inhibited the epithelial-mesenchymal transition in breast cancer cells, as evidenced by an increase in E-cadherin and a drop in N-cadherin, and inhibited breast cancer cell survival, as evidenced by the activation of the phosphoinositide 3-kinase/Akt pathway. Taken together, these findings demonstrate that fucoidan inhibits breast cancer progression by regulating the miR-29c/ADAM12 and miR-17-5p/PTEN axes. Fucoidan is a potential chemopreventive/chemotherapeutic agent for breast cancer.
原文英語
頁（從 - 到）2408-2419
頁數12
期刊Journal of Cancer
卷7
發行號15
DOIs
出版狀態已發佈 - 2016

指紋

Disintegrins
Seaweed
Metalloproteases
MicroRNAs
Phosphoric Monoester Hydrolases
Breast Neoplasms
Neoplasms
Cadherins
Epithelial-Mesenchymal Transition
1-Phosphatidylinositol 4-Kinase
3' Untranslated Regions
Luciferases
fucoidan
Tensins
Cell Survival
Down-Regulation
Genes

ASJC Scopus subject areas

  • Oncology

引用此文

Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. / Wu, Szu Yuan; Yan, Ming De; Wu, Alexander T H; Yuan, Kevin Sheng Po; Liu, Shing Hwa.

於: Journal of Cancer, 卷 7, 編號 15, 2016, p. 2408-2419.

研究成果: 雜誌貢獻 › 文章

Wu, SY, Yan, MD, Wu, ATH, Yuan, KSP & Liu, SH 2016, 'Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells', Journal of Cancer, 卷 7, 編號 15, 頁 2408-2419. https://doi.org/10.7150/jca.15703
Wu SY, Yan MD, Wu ATH, Yuan KSP, Liu SH. Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. Journal of Cancer. 2016;7(15):2408-2419. https://doi.org/10.7150/jca.15703
Wu, Szu Yuan ; Yan, Ming De ; Wu, Alexander T H ; Yuan, Kevin Sheng Po ; Liu, Shing Hwa. / Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. 於: Journal of Cancer. 2016 ; 卷 7, 編號 15. 頁 2408-2419.
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abstract = "In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and phosphatase and tensin homolog (PTEN), respectively. Moreover, fucoidan reduced the luciferase activity of 3'-untranslated region reporter; treatment of cells with the miR-29c mimic or miR-17-5p inhibitor also produced similar results. These effects of fucoidan inhibited the epithelial-mesenchymal transition in breast cancer cells, as evidenced by an increase in E-cadherin and a drop in N-cadherin, and inhibited breast cancer cell survival, as evidenced by the activation of the phosphoinositide 3-kinase/Akt pathway. Taken together, these findings demonstrate that fucoidan inhibits breast cancer progression by regulating the miR-29c/ADAM12 and miR-17-5p/PTEN axes. Fucoidan is a potential chemopreventive/chemotherapeutic agent for breast cancer.",
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