摘要
原文 | 英語 |
---|---|
頁(從 - 到) | 2408-2419 |
頁數 | 12 |
期刊 | Journal of Cancer |
卷 | 7 |
發行號 | 15 |
DOIs | |
出版狀態 | 已發佈 - 2016 |
指紋
ASJC Scopus subject areas
- Oncology
引用此文
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. / Wu, Szu Yuan; Yan, Ming De; Wu, Alexander T H; Yuan, Kevin Sheng Po; Liu, Shing Hwa.
於: Journal of Cancer, 卷 7, 編號 15, 2016, p. 2408-2419.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells
AU - Wu, Szu Yuan
AU - Yan, Ming De
AU - Wu, Alexander T H
AU - Yuan, Kevin Sheng Po
AU - Liu, Shing Hwa
PY - 2016
Y1 - 2016
N2 - In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and phosphatase and tensin homolog (PTEN), respectively. Moreover, fucoidan reduced the luciferase activity of 3'-untranslated region reporter; treatment of cells with the miR-29c mimic or miR-17-5p inhibitor also produced similar results. These effects of fucoidan inhibited the epithelial-mesenchymal transition in breast cancer cells, as evidenced by an increase in E-cadherin and a drop in N-cadherin, and inhibited breast cancer cell survival, as evidenced by the activation of the phosphoinositide 3-kinase/Akt pathway. Taken together, these findings demonstrate that fucoidan inhibits breast cancer progression by regulating the miR-29c/ADAM12 and miR-17-5p/PTEN axes. Fucoidan is a potential chemopreventive/chemotherapeutic agent for breast cancer.
AB - In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and phosphatase and tensin homolog (PTEN), respectively. Moreover, fucoidan reduced the luciferase activity of 3'-untranslated region reporter; treatment of cells with the miR-29c mimic or miR-17-5p inhibitor also produced similar results. These effects of fucoidan inhibited the epithelial-mesenchymal transition in breast cancer cells, as evidenced by an increase in E-cadherin and a drop in N-cadherin, and inhibited breast cancer cell survival, as evidenced by the activation of the phosphoinositide 3-kinase/Akt pathway. Taken together, these findings demonstrate that fucoidan inhibits breast cancer progression by regulating the miR-29c/ADAM12 and miR-17-5p/PTEN axes. Fucoidan is a potential chemopreventive/chemotherapeutic agent for breast cancer.
KW - ADAM12
KW - Breast cancer cells
KW - Fucoidan
KW - MiR-17-5p
KW - MiR-29c
KW - PTEN
UR - http://www.scopus.com/inward/record.url?scp=85006963777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006963777&partnerID=8YFLogxK
U2 - 10.7150/jca.15703
DO - 10.7150/jca.15703
M3 - Article
AN - SCOPUS:85006963777
VL - 7
SP - 2408
EP - 2419
JO - Journal of Cancer
JF - Journal of Cancer
SN - 1837-9664
IS - 15
ER -