Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: Role of tachykinins

Chun-Chun Hsu, Ruei-Lung Lin, You-Shuei Lin, Lu-Yuan Lee

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Hsu CC, Lin RL, Lin YS, Lee LY. Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: role of tachykinins. J Appl Physiol 115: 688-696, 2013. First published July 11, 2013; doi:10.1152/ japplphysiol.00491.2013.-This study was carried out to determine the effect of allergic inflammation on the airway response to increasing airway temperature. Our results showed the following: 1) In Brown-Norway rats actively sensitized by ovalbumin (Ova), isocapnic hyperventilation with humidified warm air (HWA) for 2 min raised tracheal temperature (Ttr) from 33.4 ± 0.6°C to 40.6 ± 0.1°C, which induced an immediate and sustained ( >10 min) increase in total pulmonary resistance (RL) from 0.128 ± 0.004 to 0.212 ± 0.013 cmH2O·ml ·1·s (n = 6, P <0.01). In sharp contrast, the HWA challenge caused the same increase in Ttr but did not generate any increase in RL in control rats. 2) The increase in RL in sensitized rats was reproducible when the same HWA challenge was repeated 60-90 min later. 3) This bronchoconstrictive effect was temperature dependent: a slightly smaller increase in peak Ttr (39.6 ± 0.2°C) generated a significant but smaller increase in RL in sensitized rats. 4) The HWA-induced bronchoconstriction was not generated by the humidity delivered by the HWA challenge alone, because the same water content delivered by saline aerosol at room temperature had no effect. 5) The HWA-evoked increase in RL in sensitized rats was not blocked by atropine but was completely prevented by pretreatment either with a combination of neurokinin (NK)-1 and NK-2 antagonists or with formoterol, a β2 agonist, before the HWA challenge. This study showed that increasing airway temperature evoked a pronounced and reversible increase in airway resistance in sensitized rats and that tachykinins released from the vagal bronchopulmonary C-fiber endings were primarily responsible.
原文英語
頁(從 - 到)688-696
頁數9
期刊Journal of Applied Physiology
115
發行號5
DOIs
出版狀態已發佈 - 九月 1 2013

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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