Briaviolides k-n, new briarane-type diterpenoids from cultured octocoral briareum violaceum

Jing Hao Xu, Kuei Hung Lai, Yin Di Su, Yu Chia Chang, Bo Rong Peng, Anders Backlund, Zhi Hong Wen, Ping Jyun Sung

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Four new briarane diterpenoids, briaviolides K-N (1-4), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 1-4 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW 264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages.
原文英語
文章編號75
期刊Marine Drugs
16
發行號3
DOIs
出版狀態已發佈 - 2018
對外發佈

ASJC Scopus subject areas

  • 藥物發現

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