Breakthrough candidemia in children: Clinical and microbiological characteristics, therapeutic strategies and impact on outcomes

Mei Yin Lai, Jen Fu Hsu, Shih Ming Chu, I. Hsyuan Wu, Hsuan Rong Huang, Chun Chih Lin, I-Ta Lee, Ming Chou Chiang, Ren Huei Fu, Ming Horng Tsai

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Aim: To assess the characteristics, treatments, risk factors and outcomes of breakthrough candidemia in children. Materials & methods: Episodes of breakthrough candidemia in children were compared with the remaining episodes in a 13-year cohort study. Results: Out of 319 episodes, 45 (14.1%) were breakthrough candidemia. Breakthrough candidemia occurred in patients with more acutely ill conditions, and the majority was caused by non-albicans Candida species (73.3%; 33 episodes). A total of 79.1% of breakthrough candidemia were caused by antifungal-susceptible Candida isolates and emergence of resistance was the mechanism in five cases of patients receiving fluconazole. Episodes of breakthrough candidemia had significantly higher illness severity and higher rates of fungemia-attributable mortality. Conclusion: Breakthrough candidemia independently contributed to unfavorable outcomes, and more aggressive treatment strategies are warranted when breakthrough candidemia is encountered.
原文英語
頁(從 - 到)695-705
頁數11
期刊Future Microbiology
12
發行號8
DOIs
出版狀態已發佈 - 6月 1 2017
對外發佈

ASJC Scopus subject areas

  • 微生物學
  • 微生物學(醫學)

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