Brain, the last fortress of sarcoma: Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma

Yi Sheng Chou, Chun Yu Liu, Wei Ming Chen, Tain Hsiung Chen, Paul Chih Hsueh Chen, Hung Ta Hondar Wu, Cheng Ying Shiau, Yu Chung Wu, Chien Lin Liu, Ta Chung Chao, Cheng Hwai Tzeng, Tai-Tong Wong, Chueh Chuan Yen

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. Methods Sarcoma patients treated at one institute within 10-year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person-years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed. Results Among 611 sarcoma patients, 20 (3.3%) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9% at 5 years and 8.4% at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non-surgically treated patients. Conclusion Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765-770. © 2011 Wiley Periodicals, Inc.

原文英語
頁(從 - 到)765-770
頁數6
期刊Journal of Surgical Oncology
104
發行號7
DOIs
出版狀態已發佈 - 十二月 1 2011
對外發佈Yes

指紋

Sarcoma
Neoplasm Metastasis
Bone and Bones
Brain
Alveolar Soft Part Sarcoma
Survival
Incidence
Osteosarcoma
Histology

ASJC Scopus subject areas

  • Surgery
  • Oncology

引用此文

Brain, the last fortress of sarcoma : Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma. / Chou, Yi Sheng; Liu, Chun Yu; Chen, Wei Ming; Chen, Tain Hsiung; Chen, Paul Chih Hsueh; Wu, Hung Ta Hondar; Shiau, Cheng Ying; Wu, Yu Chung; Liu, Chien Lin; Chao, Ta Chung; Tzeng, Cheng Hwai; Wong, Tai-Tong; Yen, Chueh Chuan.

於: Journal of Surgical Oncology, 卷 104, 編號 7, 01.12.2011, p. 765-770.

研究成果: 雜誌貢獻文章

Chou, YS, Liu, CY, Chen, WM, Chen, TH, Chen, PCH, Wu, HTH, Shiau, CY, Wu, YC, Liu, CL, Chao, TC, Tzeng, CH, Wong, T-T & Yen, CC 2011, 'Brain, the last fortress of sarcoma: Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma', Journal of Surgical Oncology, 卷 104, 編號 7, 頁 765-770. https://doi.org/10.1002/jso.22011
Chou, Yi Sheng ; Liu, Chun Yu ; Chen, Wei Ming ; Chen, Tain Hsiung ; Chen, Paul Chih Hsueh ; Wu, Hung Ta Hondar ; Shiau, Cheng Ying ; Wu, Yu Chung ; Liu, Chien Lin ; Chao, Ta Chung ; Tzeng, Cheng Hwai ; Wong, Tai-Tong ; Yen, Chueh Chuan. / Brain, the last fortress of sarcoma : Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma. 於: Journal of Surgical Oncology. 2011 ; 卷 104, 編號 7. 頁 765-770.
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title = "Brain, the last fortress of sarcoma: Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma",
abstract = "Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. Methods Sarcoma patients treated at one institute within 10-year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person-years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed. Results Among 611 sarcoma patients, 20 (3.3{\%}) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9{\%} at 5 years and 8.4{\%} at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non-surgically treated patients. Conclusion Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765-770. {\circledC} 2011 Wiley Periodicals, Inc.",
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T1 - Brain, the last fortress of sarcoma

T2 - Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma

AU - Chou, Yi Sheng

AU - Liu, Chun Yu

AU - Chen, Wei Ming

AU - Chen, Tain Hsiung

AU - Chen, Paul Chih Hsueh

AU - Wu, Hung Ta Hondar

AU - Shiau, Cheng Ying

AU - Wu, Yu Chung

AU - Liu, Chien Lin

AU - Chao, Ta Chung

AU - Tzeng, Cheng Hwai

AU - Wong, Tai-Tong

AU - Yen, Chueh Chuan

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. Methods Sarcoma patients treated at one institute within 10-year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person-years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed. Results Among 611 sarcoma patients, 20 (3.3%) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9% at 5 years and 8.4% at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non-surgically treated patients. Conclusion Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765-770. © 2011 Wiley Periodicals, Inc.

AB - Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. Methods Sarcoma patients treated at one institute within 10-year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person-years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed. Results Among 611 sarcoma patients, 20 (3.3%) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9% at 5 years and 8.4% at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non-surgically treated patients. Conclusion Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765-770. © 2011 Wiley Periodicals, Inc.

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