Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects

Chao Ping Wang, Wei Chin Hung, Teng Hung Yu, Hui-Ling Hsu, Yen Hsun Chen, Cheng An Chiu, Li Fen Lu, Fu Mei Chung, Ya Ai Cheng, Yau Jiunn Lee

研究成果: 雜誌貢獻文章

18 引文 (Scopus)

摘要

While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.

原文英語
頁(從 - 到)31-43
頁數13
期刊Clinical and Experimental Hypertension
31
發行號1
DOIs
出版狀態已發佈 - 二月 1 2009
對外發佈Yes

指紋

Pulse Wave Analysis
Left Ventricular Function
Ankle
Arm
Thigh
Vascular Stiffness
Left Ventricular Dysfunction
Hypertension
Heart Sounds

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

引用此文

Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects. / Wang, Chao Ping; Hung, Wei Chin; Yu, Teng Hung; Hsu, Hui-Ling; Chen, Yen Hsun; Chiu, Cheng An; Lu, Li Fen; Chung, Fu Mei; Cheng, Ya Ai; Lee, Yau Jiunn.

於: Clinical and Experimental Hypertension, 卷 31, 編號 1, 01.02.2009, p. 31-43.

研究成果: 雜誌貢獻文章

Wang, CP, Hung, WC, Yu, TH, Hsu, H-L, Chen, YH, Chiu, CA, Lu, LF, Chung, FM, Cheng, YA & Lee, YJ 2009, 'Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects', Clinical and Experimental Hypertension, 卷 31, 編號 1, 頁 31-43. https://doi.org/10.1080/10641960802409796
Wang, Chao Ping ; Hung, Wei Chin ; Yu, Teng Hung ; Hsu, Hui-Ling ; Chen, Yen Hsun ; Chiu, Cheng An ; Lu, Li Fen ; Chung, Fu Mei ; Cheng, Ya Ai ; Lee, Yau Jiunn. / Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects. 於: Clinical and Experimental Hypertension. 2009 ; 卷 31, 編號 1. 頁 31-43.
@article{01e469bba46642489f0fac46ea08d940,
title = "Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects",
abstract = "While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.",
keywords = "Arterial stiffness, Brachial-ankle pulse wave velocity, Hypertension, LV diastolic function, Tissue Doppler imaging",
author = "Wang, {Chao Ping} and Hung, {Wei Chin} and Yu, {Teng Hung} and Hui-Ling Hsu and Chen, {Yen Hsun} and Chiu, {Cheng An} and Lu, {Li Fen} and Chung, {Fu Mei} and Cheng, {Ya Ai} and Lee, {Yau Jiunn}",
year = "2009",
month = "2",
day = "1",
doi = "10.1080/10641960802409796",
language = "English",
volume = "31",
pages = "31--43",
journal = "Clinical and Experimental Hypertension",
issn = "1064-1963",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects

AU - Wang, Chao Ping

AU - Hung, Wei Chin

AU - Yu, Teng Hung

AU - Hsu, Hui-Ling

AU - Chen, Yen Hsun

AU - Chiu, Cheng An

AU - Lu, Li Fen

AU - Chung, Fu Mei

AU - Cheng, Ya Ai

AU - Lee, Yau Jiunn

PY - 2009/2/1

Y1 - 2009/2/1

N2 - While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.

AB - While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.

KW - Arterial stiffness

KW - Brachial-ankle pulse wave velocity

KW - Hypertension

KW - LV diastolic function

KW - Tissue Doppler imaging

UR - http://www.scopus.com/inward/record.url?scp=60549087174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60549087174&partnerID=8YFLogxK

U2 - 10.1080/10641960802409796

DO - 10.1080/10641960802409796

M3 - Article

C2 - 19172457

AN - SCOPUS:60549087174

VL - 31

SP - 31

EP - 43

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

SN - 1064-1963

IS - 1

ER -