Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development

Chi Huang Chen, I. Ching Chen, Yu Chi Wang, Jah Yao Liu, Gwo Jang Wu, Chii Ruey Tzeng

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Objective: To present male gender preselection after successive gestational hyperandrogenism and female pseudohermaphroditism by pregnancy luteomas. Design: Case report. Setting: University-based teaching hospital. Patient(s): We describe herein a gravida who presented two successive 46, XX disorders of sex development with apparent female genitalia with an enlarged clitoris due to maternal androgen excess from pregnancy luteoma. The maternal hyperandrogenemia returned to a normal level and bilateral luteoma regressed spontaneously postpartum. After gender preselection by Y-bearing spermatozoa for intrauterine insemination at the third gestation, a healthy boy was born in spite of the exaggerated maternal androgen production of pregnancy luteoma to avoid 46, XX disorders of sex development. Intervention(s): Y-bearing spermatozoa for intrauterine insemination as male gender preselection. Main Outcome Measure(s): Boy born after gender preselection for intrauterine insemination and cesarean section. Result(s): Healthy boy born without disorder of sex development after antenatal maternal androgen excess of ovarian luteoma. Conclusion(s): Successive pregnancy luteomas associated with maternal hyperandrogenism may cause female disorders of sex development. Male preselection ameliorates the insult of external genitalia ambiguity by antenatal androgen excess in this matter of concern.

原文英語
頁(從 - 到)2732.e5-2732.e7
期刊Fertility and Sterility
91
發行號6
DOIs
出版狀態已發佈 - 六月 2009

ASJC Scopus subject areas

  • 生殖醫學
  • 婦產科

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