Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect

R. G. Gbaw, R. A. Yankee, G. N. Rogentine, B. G. Leventhal, G. P. Herzig, R. H. Halterman, C. B. Merritt, M. H. McGinniss, G. R.D. Krueger, J. Whang-Peng, R. L. Carolla, D. S. Gullion, M. E. Lippman, H. R. Gralnick, C. W. Berard, P. I. Terasaki, E. S. Henderson

研究成果: 雜誌貢獻文章

19 引文 (Scopus)

摘要

Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.
原文英語
頁(從 - 到)79-90
頁數12
期刊Transplantation
14
發行號1
出版狀態已發佈 - 一月 1 1972
對外發佈Yes

指紋

Bone Marrow Transplantation
Leukemia
Tissue Donors
Bone Marrow
Transplants
Leukocytes
Immunoglobulin Allotypes
Cytomegalovirus Infections
Immunosuppressive Agents
HLA Antigens
Karyotype
Siblings
Transplantation
Erythrocytes
Drug Therapy
Survival

ASJC Scopus subject areas

  • Transplantation

引用此文

Gbaw, R. G., Yankee, R. A., Rogentine, G. N., Leventhal, B. G., Herzig, G. P., Halterman, R. H., ... Henderson, E. S. (1972). Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect. Transplantation, 14(1), 79-90.

Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia : Toxicity and antileukemic effect. / Gbaw, R. G.; Yankee, R. A.; Rogentine, G. N.; Leventhal, B. G.; Herzig, G. P.; Halterman, R. H.; Merritt, C. B.; McGinniss, M. H.; Krueger, G. R.D.; Whang-Peng, J.; Carolla, R. L.; Gullion, D. S.; Lippman, M. E.; Gralnick, H. R.; Berard, C. W.; Terasaki, P. I.; Henderson, E. S.

於: Transplantation, 卷 14, 編號 1, 01.01.1972, p. 79-90.

研究成果: 雜誌貢獻文章

Gbaw, RG, Yankee, RA, Rogentine, GN, Leventhal, BG, Herzig, GP, Halterman, RH, Merritt, CB, McGinniss, MH, Krueger, GRD, Whang-Peng, J, Carolla, RL, Gullion, DS, Lippman, ME, Gralnick, HR, Berard, CW, Terasaki, PI & Henderson, ES 1972, 'Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect', Transplantation, 卷 14, 編號 1, 頁 79-90.
Gbaw RG, Yankee RA, Rogentine GN, Leventhal BG, Herzig GP, Halterman RH 等. Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect. Transplantation. 1972 1月 1;14(1):79-90.
Gbaw, R. G. ; Yankee, R. A. ; Rogentine, G. N. ; Leventhal, B. G. ; Herzig, G. P. ; Halterman, R. H. ; Merritt, C. B. ; McGinniss, M. H. ; Krueger, G. R.D. ; Whang-Peng, J. ; Carolla, R. L. ; Gullion, D. S. ; Lippman, M. E. ; Gralnick, H. R. ; Berard, C. W. ; Terasaki, P. I. ; Henderson, E. S. / Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia : Toxicity and antileukemic effect. 於: Transplantation. 1972 ; 卷 14, 編號 1. 頁 79-90.
@article{2e984f83d4c74ac7a548b2836c614768,
title = "Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect",
abstract = "Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.",
author = "Gbaw, {R. G.} and Yankee, {R. A.} and Rogentine, {G. N.} and Leventhal, {B. G.} and Herzig, {G. P.} and Halterman, {R. H.} and Merritt, {C. B.} and McGinniss, {M. H.} and Krueger, {G. R.D.} and J. Whang-Peng and Carolla, {R. L.} and Gullion, {D. S.} and Lippman, {M. E.} and Gralnick, {H. R.} and Berard, {C. W.} and Terasaki, {P. I.} and Henderson, {E. S.}",
year = "1972",
month = "1",
day = "1",
language = "English",
volume = "14",
pages = "79--90",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia

T2 - Toxicity and antileukemic effect

AU - Gbaw, R. G.

AU - Yankee, R. A.

AU - Rogentine, G. N.

AU - Leventhal, B. G.

AU - Herzig, G. P.

AU - Halterman, R. H.

AU - Merritt, C. B.

AU - McGinniss, M. H.

AU - Krueger, G. R.D.

AU - Whang-Peng, J.

AU - Carolla, R. L.

AU - Gullion, D. S.

AU - Lippman, M. E.

AU - Gralnick, H. R.

AU - Berard, C. W.

AU - Terasaki, P. I.

AU - Henderson, E. S.

PY - 1972/1/1

Y1 - 1972/1/1

N2 - Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.

AB - Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.

UR - http://www.scopus.com/inward/record.url?scp=0015372260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015372260&partnerID=8YFLogxK

M3 - Article

C2 - 4402527

AN - SCOPUS:0015372260

VL - 14

SP - 79

EP - 90

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 1

ER -