Bone changes in the mandible following botulinum neurotoxin injections

Chi Yang Tsai, Yi Ming Shyr, Wan Chi Chiu, Chi Ming Lee

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

摘要

In this study, botulinum neurotoxin type A (BoTx/A) was injected into the temporalis and masseter muscles of growing rats to induce masticatory hypoactivity. Sixty, 30-day-old, male Long-Evans rats were randomly divided into four groups. BoTx/A was bilaterally injected in the masseter muscles in group I, in the temporalis muscles in group II, and into both the masseter and the temporalis muscles in group III. Group IV served as the control in which saline was bilaterally injected into both muscles. Forty-five days after the injections, the rats were sacrificed. Observation of cortical bone thickness from bone biopsies of the right halves of the mandibles, evaluation of the volume of masseter and temporalis muscles with a plethysmometer, and scanning of bone mineral density (BMD) of the skull and mandibular bone structure with dual-energy X-ray absorptiometry were performed. One-way analysis of variance was employed to analyse measurements of muscle volume, BMD, and cortical bone thickness among the groups. The least square difference was then used to determine significance. Reduced cortical bone thickness and BMD of the skull and mandibular bone structure were observed. The volumes of the temporalis and masseter muscles injected with BoTx/A were smaller. Masticatory hypofunction affects bone structure during development.
原文英語
頁(從 - 到)132-138
頁數7
期刊European Journal of Orthodontics
33
發行號2
DOIs
出版狀態已發佈 - 四月 2011

ASJC Scopus subject areas

  • Orthodontics

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