BN-063, a newly synthesized adenosine A1 receptor agonist, attenuates myocardial reperfusion injury in rats

Yen Mei Lee, Joen Rong Sheu, Mao Hsiung Yen

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

To assess the efficacy of the newly synthesized selective adenosine A1 receptor agonist, BN-063 (1-cyclopropylisoguanosine), against myocardial reperfusion injury, 31 rats underwent 45 min of left coronary artery occlusion and 1 h of reperfusion. Animals were randomly assigned to four groups: control, I0.5-R0.5, in which BN-063 (0.5 mg/kg i.v. bolus) was administered during both ischemia and reperfusion, R-0.5 and R-1.0, in which BN-063 was administered only during reperfusion at 0.5 and 1.0 mg/kg, respectively. The area at risk was determined by intravascular injection of blue dye during coronary artery occlusion, which was performed by retightening the ligature at the end of reperfusion, and infarct size was determined by incubation of heart slices in nitro blue tetrazolium chloride. A significant reduction in infarct size, as a percentage of the area at risk, was noted with all three BN-063 treatment groups (control: 63.5 ± 4.0%, I0.5-R0.5: 39.6 ± 3.7%, R-0.5: 37.5 ± 3.5%, R-1.0: 38.1 ± 5.2%). However, the I0.5-R0.5 group did not shown a more beneficial effect than the other two BN-063-treated groups. In addition, BN-063 exerted a protective effect on the number of ventricular premature contractions associated with reperfusion (control: 906 ± 52, I0.5-R0.5: 325 ± 61, R-0.5: 321 ± 95, R-1.0: 340 ± 46). The results of this study demonstrate that BN-063, through activation of adenosine A1 receptors, exerts antiarrhythmic and anti-infarct effects during myocardial ischemia-reperfusion. Therefore, BN-063 would be useful clinically in the treatment and prevention of acute myocardial infarction.

原文英語
頁(從 - 到)251-256
頁數6
期刊European Journal of Pharmacology
279
發行號2-3
DOIs
出版狀態已發佈 - 六月 12 1995
對外發佈

ASJC Scopus subject areas

  • 藥理

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