Blunted serum erythropoietin response to anemia in patients polytransfused for β-thalassemia major

Jiann Shiuh Chen, Kai Hsin Lin, Shan Tair Wang, Chao Jung Tsao, Tsu Fuh Yeh

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Purpose: To investigate the response of erythropoietin (EPO) to anemia in patients polytransfused for β-thalassemia major. Patients and Methods: We measured the serum EPO levels and the concurrent hemoglobin (Hb) concentrations in 40 patients polytransfused for β-thalassemia major, in 18 patients with iron deficiency anemia (IDA), and 32 healthy subjects. Serum EPO levels were assayed by an enzyme immunoassay. Results: In both groups with β-thalassemia major and IDA, serum EPO levels were significantly elevated (114 ± 71 and 239 ± 217 mU/mL, respectively). There was a significant inverse correlation between log EPO values and Hb concentrations in patients with β-thalassemia major (r = 0.61; p <0.01) and IDA (r = 0.81; p <0.01). In a semilogarithmic plot, the slope of the regression line obtained in patients with β-thalassemia major was significantly lower than that of IDA (p <0.01), suggesting a blunted EPO response to anemia in patients polytransfused for β-thalassemia major. The elevation of serum EPO in patients with β-thalassemia major was poorly related to clinical variables except serum ferritin. Conclusions: We conclude that a significant inverse relationship between serum EPO levels and Hb concentration exists in patients with β-thalassemia major. However, this EPO response in patients with anemia caused by β-thalassemia major may be blunted when compared to patients with IDA.

原文英語
頁(從 - 到)140-144
頁數5
期刊Journal of Pediatric Hematology/Oncology
20
發行號2
DOIs
出版狀態已發佈 - 三月 1 1998
對外發佈Yes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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