Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies

Julia Yu Fong Chang, Yi Ping Wang, Yang Che Wu, Shih Jung Cheng, Hsin Ming Chen, Andy Sun

研究成果: 雜誌貢獻文章同行評審

37 引文 斯高帕斯(Scopus)

摘要

Background/Purpose: Vitamin B12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV)<100fL] and microcytosis (MCV<80fL), respectively. This study evaluated anemic status, MCV, serum homocysteine level, and serum gastric parietal cell antibody (GPCA) level in oral mucosal disease patients with both vitamin B12 and iron deficiencies. Methods: The blood hemoglobin (Hb), iron, vitamin B12, folic acid and homocysteine concentrations, MCV, and serum GPCA in 149 patients with both vitamin B12 and iron deficiencies were measured and compared with the corresponding data in 149 age- and sex-matched healthy control subjects. Results: We found that 54 (36.2%), 16 (10.7%), 44 (29.5%), and 36 (24.2%) patients with both vitamin B12 and iron deficiencies had Hb deficiency (men <13g/dL, women <12g/dL), folic acid deficiency (≤6mg/mL), abnormally high blood homocysteine level (>12.6μM), and serum GPCA positivity, respectively. Patients with both vitamin B12 and iron deficiencies had a significantly higher frequency of Hb deficiency, abnormally elevated blood homocysteine level, and serum GPCA positivity than healthy control subjects (all p values<0.001). Of 149 patients with both vitamin B12 and iron deficiencies, 10 (6.7%) had high MCV (<100fL), 108 (72.5%) had normal MCV (between 80fL and 99fL), and 31 (20.8%) had low MCV (<80fL). Conclusion: Approximately 73%, 30%, and 24% of patients with both vitamin B12 and iron deficiencies are found to have normal MCV, abnormally high blood homocysteine level, and serum GPCA positivity, respectively.
原文英語
頁(從 - 到)532-538
頁數7
期刊Journal of the Formosan Medical Association
114
發行號6
DOIs
出版狀態已發佈 - 6月 1 2015
對外發佈

ASJC Scopus subject areas

  • 醫藥 (全部)

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