Blood-derived, tissue engineering biomaterials

研究成果: 雜誌貢獻回顧型文獻

1 引文 (Scopus)

摘要

Fibrin sealant and platelet gels are human blood-derived, biodegradable, non toxic, surgical products obtained by mixing a fibrinogen concentrate or a platelet rich plasma with thrombin, respectively. Fibrin sealant is now a well known surgical tool increasingly used to stop or control bleeding, or to provide air and fluid tightness in many surgical situations. Platelet gels are newly developed preparations that are of specific interest because they contain numerous physiological growth factors and cytikines that are released upon the activation of blood platelets by thrombin. These growth factors, including PDGF, TGF-β 1, BMP, and VEGF have been shown to stimulate cell growth and differentiation with special clinical benefits for soft and bony tissue healing and regeneration. Platelet gels allow surgeons to manipulate the cellular environment of surgical sites and to guide tissue regeneration. A specific interest of such products is observed for the induction of osteogenesis and chondrogenesis. Advances in the preparation, clinical use, and safety of these two important classes of blood-derived biomaterials are reviewed.
原文英語
頁(從 - 到)294-304
頁數11
期刊Biomedical Engineering - Applications, Basis and Communications
16
發行號6
出版狀態已發佈 - 十二月 25 2004
對外發佈Yes

指紋

Biocompatible Materials
Tissue Engineering
Platelets
Tissue engineering
Biomaterials
Blood
Blood Platelets
Fibrin Tissue Adhesive
Gels
Thrombin
Sealants
Regeneration
Intercellular Signaling Peptides and Proteins
Chondrogenesis
Platelet-Rich Plasma
Poisons
Tissue regeneration
Osteogenesis
Fibrinogen
Vascular Endothelial Growth Factor A

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

引用此文

Blood-derived, tissue engineering biomaterials. / Burnouf, Thierry.

於: Biomedical Engineering - Applications, Basis and Communications, 卷 16, 編號 6, 25.12.2004, p. 294-304.

研究成果: 雜誌貢獻回顧型文獻

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