Blockade of isoproterenol-induced synaptic potentiation by tetra-9-aminoacridine in the rat amygdala

Su Jane Wang, Chiung Chun Huang, Kuei Sen Hsu, Jing Jane Tsai, Chao Ching Huang, Po Wu Gean

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

The effects of tetrahydro-9-aminoacridine (THA) on β-adrenoceptor activation-induced synaptic potentiation were studied in brain slices of the rat amygdala using intracellular recording techniques. To exclude the involvement of N-methyl-D-aspartate (NMDA) receptors, all the experiments were performed in the presence of NMDA receptor antagonist, D-APV (50 μM). Bath application of isoproterenol (Iso; 15 μM) results in a long-lasting enhancement of the amplitude of excitatory postsynaptic potentials (EPSPs) to 200 ± 6% of baseline. Forskolin, which directly activates adenyl cyclase, produces a similar effect suggesting that Iso may act through a cyclic AMP-dependent mechanism. Pretreatment of the slices with THA (300 μM) completely abolishes the Iso- and forskolin-induced synaptic potentiation. We hypothesize that the locus of THA/β-adrenoceptor interaction is presynaptic; the underlying mechanism is likely due to THA's depression of transmitter release via a presynaptic blockade of voltage-dependent Ca2+ channels.

原文英語
頁(從 - 到)87-90
頁數4
期刊Neuroscience Letters
214
發行號2-3
DOIs
出版狀態已發佈 - 八月 23 1996
對外發佈

ASJC Scopus subject areas

  • 神經科學 (全部)

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