Biosynthetic rates of proteins having the characteristics of glucocorticoid receptors in adipocytes of mature and senescent rats

W. C. Chang, M. T. Hoopes, G. S. Roth

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

An affinity chromatography technique has been utilized to compare the rates of putative glucocorticoid receptor biosynthesis in epididymal fat pad adipocytes of mature and senescent Wistar rats. Biosynthetic rates appear to be linear for at least 3 hours in both age groups, but are reduced by about one-half in the senescent cells. In contrast, incorporation of labeled amino acids into total protein is not altered with aging in this system. Thus, reduction in putative glucocorticoid receptor biosynthetic rate may reflect the effects of senescence on the expression of only a small part of the genome.

原文英語
頁(從 - 到)386-390
頁數5
期刊Journals of Gerontology
36
發行號4
出版狀態已發佈 - 1981
對外發佈Yes

ASJC Scopus subject areas

  • Ageing

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