Biomarkers of oxidative stress associated with the risk of potentially malignant oral disorders

T. Senghore, Y.-F. Li, F.-C. Sung, M.-H. Tsai, C.-H. Hua, C.-S. Liu, R.-J. Huang, C.-C. Yeh

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay (ELISA) kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia.
原文英語
頁(從 - 到)5211-5216
頁數6
期刊Anticancer Research
38
發行號9
出版狀態已發佈 - 2018

Keywords

  • Biomarkers
  • Leukoplakia
  • Oxidative stress
  • Potentially malignant oral disorders

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