Biological inhibitory effects of the Chinese herb danggui on brain astrocytoma

Wei Hwa Lee, Jong Shiaw Jin, Wen Chiuan Tsai, Yu Ting Chen, Wen Liang Chang, Chen Wen Yao, Lia Fa Sheu, Ann Chen

研究成果: 雜誌貢獻文章同行評審

20 引文 斯高帕斯(Scopus)

摘要

Objective: Previous studies have demonstrated the utility of the traditional Chinese herb danggui in the treatment of chronic myelogenous leukemia. Our aim was to examine whether it might similarly be used to treat glioblastoma multiforme. Methods: The lipid-soluble active ingredients of danggui were extracted with acetone (AS-AC) or chlorophenol (AS-CH) and their antiproliferative and proapoptotic effects were studied in vitro on cultured GBM 8401 cells and in vivo on tumors in nude mice. Results: After a 24-hour treatment, either AS-AC or AS-CH at a lower (50 μg/ml) and a higher concentration (100 μg/ml) significantly inhibited the proliferative activity of GBM 8401 cultured cells by 30-50%, as well as the expression of cathepsin B and vascular endothelial growth factor (VEGF). In nude mice, the growth of the tumor was inhibited by 30% by AS-CH or AS-AC (20 mg/kg; p

原文英語
頁(從 - 到)141-148
頁數8
期刊Pathobiology
73
發行號3
DOIs
出版狀態已發佈 - 2006

ASJC Scopus subject areas

  • 病理學與法醫學
  • 臨床生物化學
  • 免疫學和過敏
  • 細胞生物學

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