Bioinspired Engineering of a Bacterium-Like Metal–Organic Framework for Cancer Immunotherapy

Po Ming Chen, Wen Yu Pan, Yang Bao Miao, Yu Miao Liu, Po Kai Luo, Hieu Nghia Phung, Wen Wei Wu, Yi Hsin Ting, Ching Yen Yeh, Min Chun Chiang, Wei Tso Chia, Hsing Wen Sung

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1 引文 斯高帕斯(Scopus)

摘要

Bacteria-mediated tumor therapy (BMTT) has been known for decades; however, its clinical use is inhibited by its association with infections. To address this issue, a spiky, bacterium-like metal–organic framework (MOF), which can replicate the functional responses of BMTT without its adverse side-effects, is proposed. MOFs are synthesized in a solvothermal reaction of aluminum sulfate, ruthenium chloride hydrate, and 2-aminoterephthalic acid; they have a spherical morphology or many nanospikes on their surfaces, depending on the reaction temperature. Both spherical and spiky MOFs can function as photothermal agents, converting absorbed optical energy into local heat. Owing to their higher surface area of interaction, spiky MOFs are more easily phagocytosed by macrophages than are spherical MOFs, strengthening their immune responses. Moreover, when injected intratumorally, spiky MOFs reside significantly longer than spherical ones, enabling their use in repeated photothermal treatments. The combination of in situ vaccination with intratumorally injected bacterium-like MOFs under exposure to an near-infrared laser and the immune checkpoint blockade of systemically administered αPD-1 is evaluated in tumor-bearing mice. The results indicate that the checkpoint blockade acts synergistically with in situ vaccination to provide diverse antitumor functions of BMTT, destroying a primary tumor and suppressing tumor recurrence and metastasis.

原文英語
文章編號2003764
期刊Advanced Functional Materials
30
發行號42
DOIs
出版狀態接受/付印 - 2020
對外發佈Yes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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