Bioengineered corneas for transplantation and in vitro toxicology

Christopher R. McLaughlin, Jui-Fang Tsai, Malcolm A. Latorre, May Griffith

研究成果: 雜誌貢獻文章同行評審

33 引文 斯高帕斯(Scopus)


Bioengineered corneas have been designed to replace partial or the full-thickness of defective corneas, as an alternative to using donor tissues. They range from prosthetic devices that solely address replacement of the cornea's function, to tissue engineered hydrogels that permit regeneration of host tissues. In cases where corneal stem cells have been depleted by injury or disease, most frequently involving the superficial epithelium, tissue engineered lamellar implants reconstructed with stem cells have been transplanted. In situ methods using ultraviolet A (UVA) crosslinking have also been developed to strengthen weakened corneas. In addition to the clinical need, bioengineered corneas are also rapidly gaining importance in the area of in vitro toxicology, as alternatives to animal testing. More complex, fully innervated, physiologically active, three-dimensional organotypic models are also being tested.
頁(從 - 到)3326-3337
期刊Frontiers in Bioscience
出版狀態已發佈 - 1月 1 2009

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)
  • 免疫學與微生物學 (全部)
  • 醫藥 (全部)


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