摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 45-52 |
| 頁數 | 8 |
| 期刊 | International Journal of Biological Macromolecules |
| 卷 | 64 |
| DOIs | |
| 出版狀態 | 已發佈 - 2014 |
指紋
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Structural Biology
引用此文
Biodistribution profiling of the chemical modified hyaluronic acid derivatives used for oral delivery system. / Hsieh, Chien Ming; Huang, Yu Wen; Sheu, Ming Thau; Ho, Hsiu O.
於: International Journal of Biological Macromolecules, 卷 64, 2014, p. 45-52.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Biodistribution profiling of the chemical modified hyaluronic acid derivatives used for oral delivery system
AU - Hsieh, Chien Ming
AU - Huang, Yu Wen
AU - Sheu, Ming Thau
AU - Ho, Hsiu O.
PY - 2014
Y1 - 2014
N2 - A series of adipic acid dihydrazide (ADH)-modified hyaluronic acid (HA-ADH) compounds were synthesized and conjugated with QDots (QDots-HA conjugates) to assess the effects of the molecular weight (MW) and extent of chemical modification of HA on its biodistribution. Their physicochemical structures were confirmed by complementary application of GPC, 1H NMR, FTIR, and UV-vis spectroscopic methods. In vivo imaging of QDots-HA conjugates after oral administration was analyzed to investigate their biodistribution in nude mice. Simultaneously, real-time bioimaging was confirmed by an anatomical analysis to investigate the organ-specific accumulation of conjugates. QDot-HA conjugates with a higher MW of HA or high modification presented relatively slow clearance leading to an extension of the retention time for up to 10 days, whereas those with lower MWs of HA or a low modification extent exhibited quick absorption and elimination after oral administration. Taken together, HA derivatives with suitable MWs and chemical modification extents can be used to design new, more-sophisticated, and intelligent HA-based vehicles for oral delivery with diverse characteristics.
AB - A series of adipic acid dihydrazide (ADH)-modified hyaluronic acid (HA-ADH) compounds were synthesized and conjugated with QDots (QDots-HA conjugates) to assess the effects of the molecular weight (MW) and extent of chemical modification of HA on its biodistribution. Their physicochemical structures were confirmed by complementary application of GPC, 1H NMR, FTIR, and UV-vis spectroscopic methods. In vivo imaging of QDots-HA conjugates after oral administration was analyzed to investigate their biodistribution in nude mice. Simultaneously, real-time bioimaging was confirmed by an anatomical analysis to investigate the organ-specific accumulation of conjugates. QDot-HA conjugates with a higher MW of HA or high modification presented relatively slow clearance leading to an extension of the retention time for up to 10 days, whereas those with lower MWs of HA or a low modification extent exhibited quick absorption and elimination after oral administration. Taken together, HA derivatives with suitable MWs and chemical modification extents can be used to design new, more-sophisticated, and intelligent HA-based vehicles for oral delivery with diverse characteristics.
KW - Chemical modification
KW - Hyaluronic acid
KW - In vivo imaging
KW - Oral administration
KW - Quantum dots
UR - http://www.scopus.com/inward/record.url?scp=84890279793&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890279793&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2013.11.027
DO - 10.1016/j.ijbiomac.2013.11.027
M3 - Article
C2 - 24315950
AN - SCOPUS:84890279793
VL - 64
SP - 45
EP - 52
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
SN - 0141-8130
ER -