Biodegradable poly([D,L]-lactide-co-glycolide) nanofibers for the sustainable delivery of lidocaine into the epidural space after laminectomy

Yuan Yun Tseng, Jun Yi Liao, Wei An Chen, Yu Chun Kao, Shih Jung Liu

研究成果: 雜誌貢獻文章同行評審

23 引文 斯高帕斯(Scopus)

摘要

Aim: We developed biodegradable, lidocaine-embedded poly([D,L]-lactide-co- glycolide) nanofibers for epidural analgesia to reduce the severe pain in rats after laminectomies. Materials & methods: Nanofibers were prepared by an electrospinning process and were introduced into the epidural space of rats after laminectomy. The lidocaine concentration, postoperative bodyweight change and amount of food/water intake were monitored to evaluate the analgesic effectiveness of the drug-eluting nanofibers. Results: It was demonstrated that the nanofibers provided a sustained release of lidocaine for more than 2 weeks, and the local pharmaceutical concentration was much higher than the concentration in plasma. Rats that received laminectomies without nanofibers exhibited the greatest bodyweight reduction. The food/water intake and activity performance were significantly higher in rats receiving laminectomies with nanofibers than in rats without nanofibers. Conclusion: The results of this study suggest that the lidocaine-loaded nanofibers can provide an easy, practical and safe means of achieving effective postlaminectomy analgesia. Original submitted 23 April 2012; Revised submitted 25 October 2012; Published online 26 June 201.

原文英語
頁(從 - 到)77-87
頁數11
期刊Nanomedicine
9
發行號1
DOIs
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • 材料科學(全部)
  • 生物工程
  • 生物醫學工程
  • 醫藥(雜項)
  • 發展

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