Biodegradable nanoparticles for gene therapy technology

Hossein Hosseinkhani, Wen Jie He, Chiao Hsi Chiang, Po Da Hong, Dah Shyong Yu, Abraham J. Domb, Keng Liang Ou

研究成果: 雜誌貢獻回顧型文獻同行評審

20 引文 斯高帕斯(Scopus)

摘要

Rapid propagations in materials technology together with biology have initiated great hopes in the possibility of treating many diseases by gene therapy technology. Viral and non-viral gene carriers are currently applied for gene delivery. Non-viral technology is safe and effective for the delivery of genetic materials to cells and tissues. Non-viral systems are based on plasmid expression containing a gene encoding a therapeutic protein and synthetic biodegradable nanoparticles as a safe carrier of gene. Biodegradable nanoparticles have shown great interest in drug and gene delivery systems as they are easy to be synthesized and have no side effect in cells and tissues. This review provides a critical view of applications of biodegradable nanoparticles on gene therapy technology to enhance the localization of in vitro and in vivo and improve the function of administered genes.

原文英語
文章編號1794
期刊Journal of Nanoparticle Research
15
發行號7
DOIs
出版狀態已發佈 - 七月 2013

ASJC Scopus subject areas

  • 生物工程
  • 化學 (全部)
  • 原子與分子物理與光學
  • 建模與模擬
  • 材料科學(全部)
  • 凝聚態物理學

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