Bioconversion of ginsenosides in american ginseng extraction residue by fermentation with ganoderma lucidum improves insulin-like glucose uptake in 3t3-l1 adipocytes

Bo Yang Hsu, Chia Hui Chen, Ting Jang Lu, Min Hsiung Pan, Chi Tang Ho, Lucy Sun Hwang, Wei Lun Hung

研究成果: 雜誌貢獻文章同行評審

摘要

Ginseng is one of the most popular traditional Chinese medicines that have been widely used in China and other Asian countries for thousands of years. Ginsenosides are the unique bioactive saponins occurring in ginseng, and their biological activities have been extensively investigated. A large amount of ginseng residue is produced as waste product due to its applications in manufacturing functional food products, even though it may still contain bioactive components. Thus, the objective of this study was to investigate the hypoglycemic activities of American ginseng extraction residue (AmR) via fermentation with Ganoderma lucidum. Our results showed that the total phenolic contents and β-glucosidase activity of AmR profoundly increased after fermentation with G. lucidum. In 3T3-L1 adipocytes, stimulation of glucose uptake by treatment with AmR was not significant, while fermented AmR (FAmR) exhibited insulin-like glucose-uptake-stimulatory effects. Importantly, the hypoglycemic effects of FAmR were positively associated with the amount of the deglycosylated minor ginsenosides Rg1, Rg3, and compound K. Taken together, our current findings suggest that bioconversion of AmR by fermentation with G. lucidum may be a feasible and eco-friendly approach to developing a functional ingredient for the management of diabetes, while also resolving the problem of ginseng waste.
原文英語
文章編號297
期刊Fermentation
7
發行號4
DOIs
出版狀態已發佈 - 12月 2021

ASJC Scopus subject areas

  • 食品科學
  • 生物化學、遺傳與分子生物學(雜項)
  • 植物科學

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