Biocompatible and multifunctional gold nanorods for effective photothermal therapy of oral squamous cell carcinoma

Yu Te Liao, Chia Hung Liu, Yin Chin, Sin Yuan Chen, Shing Hwa Liu, Yih Chih Hsu, Kevin C.W. Wu

研究成果: 雜誌貢獻文章同行評審

24 引文 斯高帕斯(Scopus)

摘要

Herein, a cysteine-functionalized alginate was used to replace cytotoxic cetyltrimethylammonium bromide (CTAB) on gold nanorods (GNRs) by gold-thiol bonding. The characterization shows that the alginate-modified GNRs (GNR@Alg-Cys) were 137 nm in length (measured by zetasizer) with a negative surface charge (-28.4 mV). The GNR@Alg-Cys showed an intense absorption at 800 nm, indicating the potential of GNR@Alg-Cys for NIR-excited photothermal therapy (PTT). To target cancer cells, a cyclic peptide, c(RGDfK)KKK, was further modified on GNR@Alg-Cys (denoted as GNR@Alg-Cys/RGD). In vitro experiments reveal the apparently enhanced cell viability under a high dose of GNRs as well as the death of SAS-3 cell lines exposed to a single-wavelength laser (808 nm). The animal study revealed that the volume of GNR@Alg-Cys/RGD-treated laser-exposed tumor was reduced five times when compared with that in the case of the control group (PBS-treated tumor). Furthermore, the in vivo toxicity of GNR@Alg-Cys/RGD was evaluated, and no significant effect was observed on the functions of liver and kidneys after PTT.
原文英語
頁(從 - 到)4451-4460
頁數10
期刊Journal of Materials Chemistry B
7
發行號28
DOIs
出版狀態已發佈 - 2019

ASJC Scopus subject areas

  • 化學 (全部)
  • 生物醫學工程
  • 材料科學(全部)

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