Biocompatibility and biological performance evaluation of additive-manufactured bioabsorbable iron-based porous suture anchor in a rabbit model

Chien Cheng Tai, Hon Lok Lo, Chen Kun Liaw, Yu Min Huang, Yen Hua Huang, Kuo Yi Yang, Chih Chieh Huang, Shin I. Huang, Hsin Hsin Shen, Tzu Hung Lin, Chun Kuan Lu, Wen Chih Liu, Jui Sheng Sun, Pei I. Tsai, Chih Yu Chen

研究成果: 雜誌貢獻文章同行評審

摘要

This study evaluated the biocompatibility and biological performance of novel additive-man-ufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double-and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respec-tively), were compared with the synthetic polymer-based bioabsorbable suture anchor (poly-mer_SAs). An in vitro mechanical test, MTT assay, and scanning electron microscope (SEM) analysis were performed. An in vivo animal study was also performed. The three types of suture anchors were randomly implanted in the outer cortex of the lateral femoral condyle. The ultimate in vitro pullout strength of the iron_SA_3_helix group was significantly higher than the iron_SA_2_helix and polymer_SA groups. The MTT assay findings demonstrated no significant cytotoxicity, and the SEM analysis showed cells attachment on implant surface. The ultimate failure load of the iron_SA_3_helix group was significantly higher than that of the polymer_SA group. The micro-CT analysis indicated the iron_SA_3_helix group showed a higher bone volume fraction (BV/TV) after surgery. Moreover, both iron SAs underwent degradation with time. Iron_SAs with triple-helical threads and a porous structure demonstrated better mechanical strength and high biocompatibility after short-term implantation. The combined advantages of the mechanical superiority of the iron metal and the possibility of absorption after implantation make the iron_SA a suitable candidate for further development.
原文英語
文章編號7368
期刊International journal of molecular sciences
22
發行號14
DOIs
出版狀態已發佈 - 七月 2 2021

ASJC Scopus subject areas

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

指紋

深入研究「Biocompatibility and biological performance evaluation of additive-manufactured bioabsorbable iron-based porous suture anchor in a rabbit model」主題。共同形成了獨特的指紋。

引用此