Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites

Charles J. Choi, Hsin Yu Wu, Sherine George, Jonathan Weyhenmeyer, Brian T. Cunningham

研究成果: 雜誌貢獻文章同行評審

34 引文 斯高帕斯(Scopus)

摘要

In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug injection and point-of-care health monitoring. In this work, we incorporated a surface-enhanced Raman scattering (SERS) sensor comprised of an array of closely spaced metal nanodomes into flexible tubing commonly used for IV drug delivery and urinary catheters. The nanodome sensor was fabricated by a low-cost, large-area process that enables single use disposable operation. As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges. Distinct SERS peaks for each analyte were used to demonstrate separate detection and co-detection of the analytes.

原文英語
頁(從 - 到)574-581
頁數8
期刊Lab on a Chip - Miniaturisation for Chemistry and Biology
12
發行號3
DOIs
出版狀態已發佈 - 二月 7 2012
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 化學 (全部)
  • 生物工程
  • 生物醫學工程

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