摘要
The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/d- galactosamine (LPS/d-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 μmol/kg trans-cinnamaldehyde, (α)- aromadendrene, T-cadinol, or α-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and α-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/d-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (α)-aromadendrene, T-cadinol, or α-cadinol significantly reduced the incidence of liver lesions induced by LPS/d-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/d-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.
原文 | 英語 |
---|---|
頁(從 - 到) | 8117-8123 |
頁數 | 7 |
期刊 | Journal of Agricultural and Food Chemistry |
卷 | 59 |
發行號 | 15 |
DOIs | |
出版狀態 | 已發佈 - 8月 10 2011 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 農業與生物科學 (全部)
- 化學 (全部)