Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)-induced acute hepatitis in mice

Yu Tang Tung, Chi Chang Huang, Shang Tse Ho, Yueh Hsiung Kuo, Chi Chen Lin, Chien Tsong Lin, Jyh Horng Wu

研究成果: 雜誌貢獻文章同行評審

34 引文 斯高帕斯(Scopus)

摘要

The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/d- galactosamine (LPS/d-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 μmol/kg trans-cinnamaldehyde, (α)- aromadendrene, T-cadinol, or α-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and α-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/d-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (α)-aromadendrene, T-cadinol, or α-cadinol significantly reduced the incidence of liver lesions induced by LPS/d-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/d-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.
原文英語
頁(從 - 到)8117-8123
頁數7
期刊Journal of Agricultural and Food Chemistry
59
發行號15
DOIs
出版狀態已發佈 - 八月 10 2011
對外發佈

ASJC Scopus subject areas

  • 農業與生物科學 (全部)
  • 化學 (全部)

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