BICD cargo adaptor 1 (BICD1) downregulation correlates with a decreased level of PD-L1 and predicts a favorable prognosis in patients with IDH1-mutant lower-grade gliomas

Shang Pen Huang, Chien Hsiu Li, Wei Min Chang, Yuan Feng Lin

研究成果: 雜誌貢獻文章同行評審

摘要

Although several biomarkers have been identified to predict the prognosis of lower-grade (Grade II/III) gliomas (LGGs), we still need to identify new markers to facilitate those well-known markers to obtain more accurate prognosis prediction in LGGs. Bioinformatics data from The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA), and the Cancer Cell Line Encyclopedia (CCLE) datasets were used as the research materials. In total, 34 genes associated with the HIF1A pathway were analyzed using the hierarchical method to search for the most compatible gene. The BICD cargo adaptor 1 (BICD1) gene (BICD1) was shown to be significantly correlated with The hypoxic inducible factor 1A (HIF1A) expression, the World Health Organization (WHO) grade, and IDH1 mutation status. In addition, BICD1 downregulation was significantly correlated with a higher Karnofsky performance score (KPS), IDH1/TP53/ATRX mutations, wild-type EGFR, and younger patient age in the enrolled LGG cohort. Moreover, BICD1 expression was significantly upregulated in wild-type IDH1 LGGs with EGFR mutations. Kaplan-Meier survival analysis revealed that BICD1 downregulation predicts a favorable overall survival (OS) in LGG patients, especially in those with IDH1 mutations. Intriguingly, we found a significant correlation between BICD1 downregulation and a decreased level of CD274, GSK3B, HGF, or STAT3 in LGGs. Our findings suggest that BICD1 downregulation could be a potential biomarker for a favorable prognosis of LGGs.
原文英語
文章編號701
期刊Biology
10
發行號8
DOIs
出版狀態已發佈 - 八月 2021

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)
  • 免疫學與微生物學 (全部)
  • 農業與生物科學 (全部)

指紋

深入研究「BICD cargo adaptor 1 (BICD1) downregulation correlates with a decreased level of PD-L1 and predicts a favorable prognosis in patients with IDH1-mutant lower-grade gliomas」主題。共同形成了獨特的指紋。

引用此