Benzophenones as xanthine oxidase inhibitors

Shiow Yunn Sheu, Hsing Jane Tsai, Hsüch Ching Chiang

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

摘要

Eight synthetic bezophenones were tested for their inhibitory effects on xanthine oxidase (XO). The enzyme, XO catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid, which has a λ max of 295 nm, forming the basis for a spectrophotometric assay for the activity of XO. The results showed that 2,2',4,4'-tetrahydroxybenzophenone (6), 3,4,5,2',3',4'-hexahydroxybenzophenone (8) and 4,4'-dihydroxybenzophenone (3) displayed the inhibitory effects on XO with an order of activity of IC50 = 47.59, 69.40 and 82.94 μM, respectively. The apparent inhibition constants (Ki) of (8) and (3) were 15.61 and 64.86 μM respectively, and both of them induced mixed type (non-competitive-uncompetitive) inhibitions of the substrate xanthine.
原文英語
頁(從 - 到)1131-1135
頁數5
期刊Anticancer Research
19
發行號2 A
出版狀態已發佈 - 1999

    指紋

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

引用此

Sheu, S. Y., Tsai, H. J., & Chiang, H. C. (1999). Benzophenones as xanthine oxidase inhibitors. Anticancer Research, 19(2 A), 1131-1135.