Baseline serum matrix metalloproteinase-9 level predicts long-term prognosis after coronary revascularizations in stable coronary artery disease

Zhong Xuan Ye, Hsin Bang Leu, Tao Cheng Wu, Shing Jong Lin, Jaw Wen Chen

研究成果: 雜誌貢獻文章

13 引文 (Scopus)

摘要

Objectives: This study aimed to investigate whether baseline serum levels of matrix metalloproteinases (MMPs) could predict long-term prognosis of coronary revascularizations. Designs and methods: Ninety-one consecutive patients receiving coronary revascularizations (58 percutaneous coronary interventions and 33 coronary artery bypass graft surgeries) for stable coronary artery disease (CAD) were studied. Baseline serum levels of high-sensitive C-reactive protein (hsCRP), MMP-2, -3 and -9 drawn before revascularization were correlated to the clinical adverse events within > 12 months after revascularizations. Results: Baseline characteristics were similar between the two groups. There were total 22 major adverse cardiovascular events during a mean period of 27 months. Only baseline serum MMP-9 level independently predicted future cardiovascular events after coronary revascularization either by multivariate analysis (relative risk 3.18, p = 0.028) or by Kaplan-Meier analysis (p = 0.021). Conclusions: Baseline serum MMP-9 level predicted the prognosis after coronary revascularizations, suggesting its potential role in risk stratification before revascularization strategies for stable CAD.

原文英語
頁(從 - 到)292-298
頁數7
期刊Clinical Biochemistry
41
發行號4-5
DOIs
出版狀態已發佈 - 三月 2008

指紋

Matrix Metalloproteinase 9
Coronary Artery Disease
Matrix Metalloproteinase 2
Serum
Matrix Metalloproteinases
Grafts
C-Reactive Protein
Surgery
Matrix Metalloproteinase 3
Kaplan-Meier Estimate
Percutaneous Coronary Intervention
Coronary Artery Bypass
Multivariate Analysis
Transplants

ASJC Scopus subject areas

  • Clinical Biochemistry

引用此文

Baseline serum matrix metalloproteinase-9 level predicts long-term prognosis after coronary revascularizations in stable coronary artery disease. / Ye, Zhong Xuan; Leu, Hsin Bang; Wu, Tao Cheng; Lin, Shing Jong; Chen, Jaw Wen.

於: Clinical Biochemistry, 卷 41, 編號 4-5, 03.2008, p. 292-298.

研究成果: 雜誌貢獻文章

@article{c3b5e5053446494cbd0cbce49f224eba,
title = "Baseline serum matrix metalloproteinase-9 level predicts long-term prognosis after coronary revascularizations in stable coronary artery disease",
abstract = "Objectives: This study aimed to investigate whether baseline serum levels of matrix metalloproteinases (MMPs) could predict long-term prognosis of coronary revascularizations. Designs and methods: Ninety-one consecutive patients receiving coronary revascularizations (58 percutaneous coronary interventions and 33 coronary artery bypass graft surgeries) for stable coronary artery disease (CAD) were studied. Baseline serum levels of high-sensitive C-reactive protein (hsCRP), MMP-2, -3 and -9 drawn before revascularization were correlated to the clinical adverse events within > 12 months after revascularizations. Results: Baseline characteristics were similar between the two groups. There were total 22 major adverse cardiovascular events during a mean period of 27 months. Only baseline serum MMP-9 level independently predicted future cardiovascular events after coronary revascularization either by multivariate analysis (relative risk 3.18, p = 0.028) or by Kaplan-Meier analysis (p = 0.021). Conclusions: Baseline serum MMP-9 level predicted the prognosis after coronary revascularizations, suggesting its potential role in risk stratification before revascularization strategies for stable CAD.",
keywords = "Coronary artery bypass graft surgery, Coronary artery disease, High-sensitive C-reactive protein, Matrix metalloproteinases, Percutaneous coronary intervention, Prognosis",
author = "Ye, {Zhong Xuan} and Leu, {Hsin Bang} and Wu, {Tao Cheng} and Lin, {Shing Jong} and Chen, {Jaw Wen}",
year = "2008",
month = "3",
doi = "10.1016/j.clinbiochem.2007.11.004",
language = "English",
volume = "41",
pages = "292--298",
journal = "Clinical Biochemistry",
issn = "0009-9120",
publisher = "Elsevier Inc.",
number = "4-5",

}

TY - JOUR

T1 - Baseline serum matrix metalloproteinase-9 level predicts long-term prognosis after coronary revascularizations in stable coronary artery disease

AU - Ye, Zhong Xuan

AU - Leu, Hsin Bang

AU - Wu, Tao Cheng

AU - Lin, Shing Jong

AU - Chen, Jaw Wen

PY - 2008/3

Y1 - 2008/3

N2 - Objectives: This study aimed to investigate whether baseline serum levels of matrix metalloproteinases (MMPs) could predict long-term prognosis of coronary revascularizations. Designs and methods: Ninety-one consecutive patients receiving coronary revascularizations (58 percutaneous coronary interventions and 33 coronary artery bypass graft surgeries) for stable coronary artery disease (CAD) were studied. Baseline serum levels of high-sensitive C-reactive protein (hsCRP), MMP-2, -3 and -9 drawn before revascularization were correlated to the clinical adverse events within > 12 months after revascularizations. Results: Baseline characteristics were similar between the two groups. There were total 22 major adverse cardiovascular events during a mean period of 27 months. Only baseline serum MMP-9 level independently predicted future cardiovascular events after coronary revascularization either by multivariate analysis (relative risk 3.18, p = 0.028) or by Kaplan-Meier analysis (p = 0.021). Conclusions: Baseline serum MMP-9 level predicted the prognosis after coronary revascularizations, suggesting its potential role in risk stratification before revascularization strategies for stable CAD.

AB - Objectives: This study aimed to investigate whether baseline serum levels of matrix metalloproteinases (MMPs) could predict long-term prognosis of coronary revascularizations. Designs and methods: Ninety-one consecutive patients receiving coronary revascularizations (58 percutaneous coronary interventions and 33 coronary artery bypass graft surgeries) for stable coronary artery disease (CAD) were studied. Baseline serum levels of high-sensitive C-reactive protein (hsCRP), MMP-2, -3 and -9 drawn before revascularization were correlated to the clinical adverse events within > 12 months after revascularizations. Results: Baseline characteristics were similar between the two groups. There were total 22 major adverse cardiovascular events during a mean period of 27 months. Only baseline serum MMP-9 level independently predicted future cardiovascular events after coronary revascularization either by multivariate analysis (relative risk 3.18, p = 0.028) or by Kaplan-Meier analysis (p = 0.021). Conclusions: Baseline serum MMP-9 level predicted the prognosis after coronary revascularizations, suggesting its potential role in risk stratification before revascularization strategies for stable CAD.

KW - Coronary artery bypass graft surgery

KW - Coronary artery disease

KW - High-sensitive C-reactive protein

KW - Matrix metalloproteinases

KW - Percutaneous coronary intervention

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=39149121494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39149121494&partnerID=8YFLogxK

U2 - 10.1016/j.clinbiochem.2007.11.004

DO - 10.1016/j.clinbiochem.2007.11.004

M3 - Article

C2 - 18067861

AN - SCOPUS:39149121494

VL - 41

SP - 292

EP - 298

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

IS - 4-5

ER -