Baseline forced expiratory volume in the first second as an independent predictor of development of the metabolic syndrome

Fone Ching Hsiao, Chung Ze Wu, Sheng Chiang Su, Ming Tsung Sun, Chang Hsun Hsieh, Yi Jen Hung, Chih Tsueng He, Dee Pei

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

A growing body of evidence strongly supports associations between reduced lung function and insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. The present study was undertaken to explore the possibility that reduced lung function is an independent predictor of development of the metabolic syndrome (MetS) and to investigate potential links between reduced lung function and the MetS. A prospective cohort study of reduced lung function as a predictor of subsequent MetS was conducted using 2-year follow-up data for 450 middle-aged adults lacking the MetS at baseline. Data were obtained from the Taipei MJ Health Screening Centers in Taiwan. The MetS was defined according to the modified Adult Treatment Panel III criteria. Over 2 years of follow-up, 26 of the 450 subjects (5.78%) without the MetS at baseline subsequently developed the syndrome. In multiple logistic regression analysis with adjustments for age, sex, body mass index, cigarette smoking, alcohol consumption, and physical activities, reduced forced expiratory volume in the first second (FEV1) at baseline remained a predictor of subsequent MetS (relative risk of 4.644, P = .036 for the third [<2.31 L] vs first [>2.88 L] tertile). In Pearson and partial correlation analyses, white blood cell counts and C-reactive protein concentrations were both found to be significantly and negatively correlated with FEV1. Lower FEV1 is concluded to serve as an independent predictor of the MetS. Low-grade systemic inflammation is the possible link between reduced lung function and the MetS.

原文英語
頁(從 - 到)848-853
頁數6
期刊Metabolism: Clinical and Experimental
59
發行號6
DOIs
出版狀態已發佈 - 六月 2010

ASJC Scopus subject areas

  • 內分泌學、糖尿病和代謝
  • 內分泌

指紋

深入研究「Baseline forced expiratory volume in the first second as an independent predictor of development of the metabolic syndrome」主題。共同形成了獨特的指紋。

引用此