BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a potential biomarker in ovarian cancer

Angel Chao, Chia Lung Tsai, Shih Ming Jung, Wei Chi Chuang, Chieh Kao, An Hsu, Shun Hua Chen, Chiao Yun Lin, Yi Chao Lee, Yun Shien Lee, Tzu Hao Wang, Hsin Shih Wang, Chyong Huey Lai

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Brain-specific angiogenesis inhibitor 1 (BAI1)-Associated protein 2-like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate (IRTKS), is involved in plasma membrane protrusion and actin formation during cell morphogenesis and migration. BAIAP2L1 is recently reported to promote cell proliferation through activation of the EGFR-ERK pathway in hepatocellular carcinoma. In this study, we report the first comprehensive study of BAIAP2L1 upregulation in human ovarian cancer. Upregulation of BAIAP2L1 in ovarian tumors was first found during RNA screening and confirmed by immunohistochemical studies on ovarian cancers and other cancer types. Significant upregulation of BAIAP2L1 in ovarian cancer was validated by analyzing multiple independent cohorts in publicly available data sets. Furthermore, BAIAP2L1 protein expression in metastatic lesions was higher than the corresponding primary tumors. Functional assays in ovarian cancer cells revealed that BAIAP2L1 is involved in promoting cell proliferation and avoiding apoptosis. In conclusion, results of this study not only indicate that BAIAP2L1 can be used as a biomarker for human ovarian cancer but also reveal its role in cancer biology. Further elucidation of the role of BAIAP2L1 in context of the insulin receptor signaling pathways of cancer cells is warranted for developing cancer therapeutics by targeting cancer-specific metabolism.

原文英語
文章編號e0133081
期刊PLoS One
10
發行號7
DOIs
出版狀態已發佈 - 七月 29 2015

指紋

Angiogenesis Inhibitors
ovarian neoplasms
Biomarkers
angiogenesis
Ovarian Neoplasms
biomarkers
Brain
brain
Proteins
proteins
neoplasms
Neoplasms
Up-Regulation
Cell proliferation
cell proliferation
Tumors
Cells
Cell Proliferation
hepatoma
MAP Kinase Signaling System

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

Chao, A., Tsai, C. L., Jung, S. M., Chuang, W. C., Kao, C., Hsu, A., ... Lai, C. H. (2015). BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a potential biomarker in ovarian cancer. PLoS One, 10(7), [e0133081]. https://doi.org/10.1371/journal.pone.0133081

BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a potential biomarker in ovarian cancer. / Chao, Angel; Tsai, Chia Lung; Jung, Shih Ming; Chuang, Wei Chi; Kao, Chieh; Hsu, An; Chen, Shun Hua; Lin, Chiao Yun; Lee, Yi Chao; Lee, Yun Shien; Wang, Tzu Hao; Wang, Hsin Shih; Lai, Chyong Huey.

於: PLoS One, 卷 10, 編號 7, e0133081, 29.07.2015.

研究成果: 雜誌貢獻文章

Chao, A, Tsai, CL, Jung, SM, Chuang, WC, Kao, C, Hsu, A, Chen, SH, Lin, CY, Lee, YC, Lee, YS, Wang, TH, Wang, HS & Lai, CH 2015, 'BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a potential biomarker in ovarian cancer', PLoS One, 卷 10, 編號 7, e0133081. https://doi.org/10.1371/journal.pone.0133081
Chao, Angel ; Tsai, Chia Lung ; Jung, Shih Ming ; Chuang, Wei Chi ; Kao, Chieh ; Hsu, An ; Chen, Shun Hua ; Lin, Chiao Yun ; Lee, Yi Chao ; Lee, Yun Shien ; Wang, Tzu Hao ; Wang, Hsin Shih ; Lai, Chyong Huey. / BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a potential biomarker in ovarian cancer. 於: PLoS One. 2015 ; 卷 10, 編號 7.
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abstract = "Brain-specific angiogenesis inhibitor 1 (BAI1)-Associated protein 2-like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate (IRTKS), is involved in plasma membrane protrusion and actin formation during cell morphogenesis and migration. BAIAP2L1 is recently reported to promote cell proliferation through activation of the EGFR-ERK pathway in hepatocellular carcinoma. In this study, we report the first comprehensive study of BAIAP2L1 upregulation in human ovarian cancer. Upregulation of BAIAP2L1 in ovarian tumors was first found during RNA screening and confirmed by immunohistochemical studies on ovarian cancers and other cancer types. Significant upregulation of BAIAP2L1 in ovarian cancer was validated by analyzing multiple independent cohorts in publicly available data sets. Furthermore, BAIAP2L1 protein expression in metastatic lesions was higher than the corresponding primary tumors. Functional assays in ovarian cancer cells revealed that BAIAP2L1 is involved in promoting cell proliferation and avoiding apoptosis. In conclusion, results of this study not only indicate that BAIAP2L1 can be used as a biomarker for human ovarian cancer but also reveal its role in cancer biology. Further elucidation of the role of BAIAP2L1 in context of the insulin receptor signaling pathways of cancer cells is warranted for developing cancer therapeutics by targeting cancer-specific metabolism.",
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