AXL is crucial for E1A-enhanced therapeutic efficiency of EGFR tyrosine kinase inhibitors through NFI in breast cancer

Chih Ming Su, Tung Wei Hsu, Shian Ying Sung, Ming Te Huang, Kuan Chou Chen, Chih Yang Huang, Chien Yi Chiang, Yen Hao Su, Hsin An Chen, Po Hsiang Liao

研究成果: 雜誌貢獻文章同行評審

摘要

AXL which is a chemosensitizer protein for breast cancer cells in response to epidermal growth factor receptor-tyrosine kinase inhibitor and suppresses tumor growth. The clinical information show nuclear factor I (NFI)-C and NFI-X expression correlate with AXL expression in breast cancer patients. Following, we establish serial deletions of AXL promoter to identify regions required for Adenovirus-5 early region 1A (E1A)-mediated AXL suppression. All of the NFI family members were extensively studied for their expression and functions in regulating AXL. Moreover, E1A post-transcriptionally downregulates AXL expression through NFI. NFI-C and NFI-X, not NFI-A and NFI-B, resulting in cell death in response to EGFR-TKI. Our finding suggests that NFI-C and NFI-X are crucial regulators for AXL and significantly correlated with poor survival of breast cancer patients.
原文英語
頁(從 - 到)1278-1287
頁數10
期刊Environmental Toxicology
36
發行號7
DOIs
出版狀態接受/付印 - 2021

ASJC Scopus subject areas

  • 毒理學
  • 管理、監督、政策法律
  • 健康、毒理學和誘變

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