Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues: A comparative study of susceptible and resistant lines

Yuen Kai T Fling, Aly M. Fadly, Lyman B. Crittenden, Hsing Jien Kung

研究成果: 雜誌貢獻 › 文章

11 引文 (Scopus)

摘要

Lymphoid leukosis (LL) is a naturally occurring neoplastic disease of chickens, caused by avian lymphoid leukosis virus (ALV). Most inbred lines of chickens, susceptible to virus infection, are also susceptible to LL development. An interesting exception is line 63 which rarely develops LL after virus infection. To obtain more information concerning the resistance of line 63 to LL, we have compared virus infection and integration in bursal tissues of resistant line 63 and a susceptible cross (1515 × 71) after virus inoculation into day-old chicks. We report here that (a) the bursa tissues in both lines are infected to similar extent and (b) the initial viral infections in both lines lead to "random" integration of proviruses in the chromosomes of the bursal tissues. Only in the tumors developing later in the susceptible line can specific integration of provirus near a cellular oncogene, c-myc, be detected. Based on these data, the mechanism of resistance of line 63 to LL is discussed.
原文英語
頁（從 - 到）411-421
頁數11
期刊Virology
卷119
發行號2
DOIs
出版狀態已發佈 - 一月 1 1982
對外發佈Yes

指紋

Avian Leukosis Virus
Virus Diseases
Virus Integration
DNA
Chickens
myc Genes
Chromosomes
Viruses
Neoplasms

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

引用此文

Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues : A comparative study of susceptible and resistant lines. / Fling, Yuen Kai T; Fadly, Aly M.; Crittenden, Lyman B.; Kung, Hsing Jien.

於: Virology, 卷 119, 編號 2, 01.01.1982, p. 411-421.

研究成果: 雜誌貢獻 › 文章

Fling, YKT, Fadly, AM, Crittenden, LB & Kung, HJ 1982, 'Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues: A comparative study of susceptible and resistant lines', Virology, 卷 119, 編號 2, 頁 411-421. https://doi.org/10.1016/0042-6822(82)90100-3
Fling YKT, Fadly AM, Crittenden LB, Kung HJ. Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues: A comparative study of susceptible and resistant lines. Virology. 1982 1月 1;119(2):411-421. https://doi.org/10.1016/0042-6822(82)90100-3
Fling, Yuen Kai T ; Fadly, Aly M. ; Crittenden, Lyman B. ; Kung, Hsing Jien. / Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues : A comparative study of susceptible and resistant lines. 於: Virology. 1982 ; 卷 119, 編號 2. 頁 411-421.
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