Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues: A comparative study of susceptible and resistant lines

Yuen Kai T Fling, Aly M. Fadly, Lyman B. Crittenden, Hsing Jien Kung

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

Lymphoid leukosis (LL) is a naturally occurring neoplastic disease of chickens, caused by avian lymphoid leukosis virus (ALV). Most inbred lines of chickens, susceptible to virus infection, are also susceptible to LL development. An interesting exception is line 63 which rarely develops LL after virus infection. To obtain more information concerning the resistance of line 63 to LL, we have compared virus infection and integration in bursal tissues of resistant line 63 and a susceptible cross (1515 × 71) after virus inoculation into day-old chicks. We report here that (a) the bursa tissues in both lines are infected to similar extent and (b) the initial viral infections in both lines lead to "random" integration of proviruses in the chromosomes of the bursal tissues. Only in the tumors developing later in the susceptible line can specific integration of provirus near a cellular oncogene, c-myc, be detected. Based on these data, the mechanism of resistance of line 63 to LL is discussed.
原文英語
頁(從 - 到)411-421
頁數11
期刊Virology
119
發行號2
DOIs
出版狀態已發佈 - 一月 1 1982
對外發佈Yes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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