Autophagy regulates ageing in C. elegans

Eszter S. Hars, Haiyan Qi, Alexey G. Ryazanov, Shengkan Jin, Li Cai, Chengcheng Hu, Leroy-Fong Liu

研究成果: 雜誌貢獻文章同行評審

155 引文 斯高帕斯(Scopus)

摘要

The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

原文英語
頁(從 - 到)93-95
頁數3
期刊Autophagy
3
發行號2
出版狀態已發佈 - 三月 2007
對外發佈Yes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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